NSMCE4A and TRIM31

Number of citations of the paper that reports this interaction (PubMedID 25590999)
60

Data Source:
BioGRID (affinity chromatography technology, pull down)

		NSMCE4A	TRIM31
Description		NSE4A component of SMC5/6 complex	tripartite motif containing 31
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Nuclear Body Smc5-Smc6 Complex	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Binding	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Protein Sumoylation Regulation Of Telomere Maintenance Chromatin Looping	Immune System Process Ubiquitin-dependent Protein Catabolic Process Inflammatory Response Protein Ubiquitination Viral Release From Host Cell Negative Regulation Of Viral Transcription NLRP3 Inflammasome Complex Assembly Innate Immune Response Positive Regulation Of DNA-templated Transcription Host-mediated Suppression Of Symbiont Invasion Defense Response To Virus Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Antiviral Innate Immune Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly
Pathways		SUMOylation of DNA damage response and repair proteins	Interferon gamma signaling
Drugs
Diseases
GWAS			Anger ( 24489884) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Beta-2 microglubulin plasma levels ( 23417110) Chronic obstructive pulmonary disease ( 33909500) Estimated glomerular filtration rate in diabetes ( 31451708) Haemorrhoidal disease ( 33888516) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Isovolumetric relaxation time ( 28394258) Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular hemoglobin ( 27863252) Neuroticism ( 29255261) Prostate cancer ( 25217961) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systemic lupus erythematosus ( 32771030) Takayasu arteritis ( 33308445) Type 1 diabetes and autoimmune thyroid diseases ( 25936594)
Interacting Genes		5 interacting genes: HSPB1 OGT SRPK1 SRPK2 TRIM31	26 interacting genes: CCT6A CFLAR EID3 IKBKG MAGEA1 MAGEA2B MAVS MKRN3 MNAT1 NSMCE4A RHBDF2 SYK TRAF2 TRIM23 TRIM27 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2K UBE2L3 UBE2N UBE2W USP7 ZSCAN1
Entrez ID		54780	11074
HPRD ID		16585	10281
Ensembl ID		ENSG00000107672	ENSG00000204616
Uniprot IDs		Q9NXX6	Q2L6J1 Q9BZY9
PDB IDs			2YSJ 2YSL
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Viral Process Regulation Of Viral Process Response To Stress Protein Modification Process Positive Regulation Of Viral Genome Replication Transferase Activity Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Response To Other Organism Negative Regulation Of Protein Kinase C Signaling Regulation Of Viral Genome Replication Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Protein K63-linked Ubiquitination Arginyl-tRNA--protein Transferase Activity Protein-containing Complex Assembly Response To External Biotic Stimulus Protein Localization To Vacuole Defense Response Regulation Of Translational Initiation Regulation Of Viral Life Cycle Protein-containing Complex Organization Regulation Of MRNA Splicing, Via Spliceosome Protein Arginylation Protein Metabolic Process Regulation Of MRNA Processing Negative Regulation Of Protein-containing Complex Assembly Innate Immune Response Protein Kinase C Inhibitor Activity Protein O-acetylglucosaminyltransferase Activity Nuclear Speck Organization Intracellular Signal Transduction Defense Response To Symbiont Regulation Of Protein Kinase C Signaling Regulation Of RNA Splicing Defense Response To Other Organism Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway Protein-RNA Complex Assembly Chromatin Organization Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Magnesium Ion Binding Carbon Catabolite Regulation Of Transcription Anterograde Axonal Protein Transport R-loop Processing Regulation Of Transcription By Glucose NSL Complex	Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Polyubiquitination Post-translational Protein Modification Protein Ubiquitination Protein Modification Process TORC1 Signaling Protein Metabolic Process TOR Signaling Protein K11-linked Ubiquitination Protein K48-linked Ubiquitination Transferase Activity Negative Regulation Of TORC1 Signaling Protein K63-linked Ubiquitination Macromolecule Metabolic Process Negative Regulation Of TOR Signaling Ubiquitin Protein Ligase Binding Regulation Of TORC1 Signaling Ubiquitin Ligase Complex Regulation Of Metabolic Process Ubiquitin Protein Ligase Activity Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Modification-dependent Protein Catabolic Process DNA Damage Response Macromolecule Catabolic Process Regulation Of TOR Signaling ATP Binding Nucleotide Binding Innate Immune Response Regulation Of Nucleobase-containing Compound Metabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Positive Regulation Of Autophagy Regulation Of Macromolecule Metabolic Process Regulation Of DNA-binding Transcription Factor Activity DNA Repair Cellular Response To Stress Defense Response To Symbiont Defense Response To Other Organism Response To Stress Nucleus Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Metabolic Process Regulation Of Telomere Maintenance Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Establishment Of Protein Localization To Telomere
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