P4HTM and PDIA2

Number of citations of the paper that reports this interaction (PubMedID 12485997)
33

Data Source:
BioGRID (pull down)

		P4HTM	PDIA2
Description		prolyl 4-hydroxylase, transmembrane	protein disulfide isomerase family A member 2
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Lumen
	Molecular Function	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Calcium Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen 2-oxoglutarate-dependent Dioxygenase Activity L-ascorbic Acid Binding Metal Ion Binding Dioxygenase Activity Hypoxia-inducible Factor-proline Dioxygenase Activity	Protein Disulfide Isomerase Activity Steroid Binding Protein Binding Lipid Binding Protein-disulfide Reductase Activity Disulfide Oxidoreductase Activity Isomerase Activity
	Biological Process	Regulation Of Erythrocyte Differentiation	Protein Folding Protein Retention In ER Lumen Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Platelet Aggregation
Pathways			Developmental Lineage of Pancreatic Acinar Cells
Drugs		Ascorbic acid
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Body mass index ( 26426971) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		9 interacting genes: DSCR9 F2RL1 GLP1R GPR37 LCOR LTB4R2 PDIA2 RHOU UBC	12 interacting genes: ACTB CALR COL2A1 CUL3 GAPDH KRTAP12-1 KRTAP6-1 MAPT P4HTM PPARG SNCA SST
Entrez ID		54681	64714
HPRD ID		17842	07617
Ensembl ID		ENSG00000178467	ENSG00000185615
Uniprot IDs		Q9NXG6	Q13087
PDB IDs		6TP5
Enriched GO Terms of Interacting Partners?		G Protein-coupled Peptide Receptor Activity G Protein-coupled Receptor Activity Proteinase-activated Receptor Activity Positive Regulation Of Glomerular Filtration Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium G Protein-coupled Receptor Signaling Pathway Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Glucagon-like Peptide 1 Receptor Activity Glucagon Receptor Activity Neuropeptide Signaling Pathway Prosaposin Receptor Activity Leukotriene B4 Receptor Activity Leukotriene Receptor Activity	Regulation Of Norepinephrine Uptake Transporter Regulator Activity Identical Protein Binding Negative Regulation Of Mitochondrial Fission Regulation Of Organelle Organization Regulation Of Multicellular Organismal Process Regulation Of Synaptic Vesicle Recycling Peptide Binding Regulation Of Protein Stability Hormone-mediated Signaling Pathway Regulation Of Mitochondrial Fission Microglial Cell Activation Amyloid Fibril Formation Leukocyte Activation Involved In Inflammatory Response Cytosol Cytoskeleton Organization Cellular Response To Oxidative Stress Kinesin Binding Tau Protein Binding Regulation Of Chromosome Organization Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Postsynapse Negative Regulation Of Gene Expression Negative Regulation Of Protein Metabolic Process Microtubule Binding Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Biological Quality Cellular Response To Chemical Stress Protein Destabilization Cellular Response To Growth Factor Stimulus Macrophage Activation Regulation Of Microtubule Polymerization Positive Regulation Of Reactive Oxygen Species Metabolic Process Response To Xenobiotic Stimulus Homeostatic Process Regulation Of Endocytosis Response To Metal Ion Response To Growth Factor Apoptotic Signaling Pathway Peptidyl-cysteine S-trans-nitrosylation Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Neurofibrillary Tangle Assembly
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