P4HTM

Description		prolyl 4-hydroxylase, transmembrane
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Calcium Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen 2-oxoglutarate-dependent Dioxygenase Activity L-ascorbic Acid Binding Metal Ion Binding Dioxygenase Activity Hypoxia-inducible Factor-proline Dioxygenase Activity
	Biological Process	Regulation Of Erythrocyte Differentiation
Pathways
Drugs		Ascorbic acid
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Novel Interacting Genes		1 novel interacting genes: QRICH1
Interacting Genes		9 interacting genes: DSCR9 F2RL1 GLP1R GPR37 LCOR LTB4R2 PDIA2 RHOU UBC
Entrez ID		54681
HPRD ID		17842
Ensembl ID		ENSG00000178467
Uniprot IDs		Q9NXG6
PDB IDs		6TP5
Enriched GO Terms of Interacting Partners?		G Protein-coupled Peptide Receptor Activity G Protein-coupled Receptor Activity Proteinase-activated Receptor Activity Positive Regulation Of Glomerular Filtration Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium G Protein-coupled Receptor Signaling Pathway Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Glucagon-like Peptide 1 Receptor Activity Glucagon Receptor Activity Neuropeptide Signaling Pathway Prosaposin Receptor Activity Leukotriene B4 Receptor Activity Leukotriene Receptor Activity
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