MIR1-2 and TRIM71

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR1-2	TRIM71
Description		microRNA 1-2	tripartite motif containing 71
Image		No pdb structure
GO Annotations	Cellular Component	RISC Complex	P-body Cytoplasm
	Molecular Function		RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Translation Repressor Activity MiRNA Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	MiRNA-mediated Post-transcriptional Gene Silencing	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Neural Tube Closure Fibroblast Growth Factor Receptor Signaling Pathway Post-transcriptional Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Translation Neural Tube Development Regulatory NcRNA-mediated Gene Silencing MiRNA Processing MiRNA-mediated Gene Silencing By Inhibition Of Translation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Protein Autoubiquitination Regulation Of MiRNA-mediated Gene Silencing 3'-UTR-mediated MRNA Destabilization Stem Cell Proliferation Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of MiRNA-mediated Gene Silencing
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Pulmonary function ( 21946350) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		78 interacting genes: ADARB1 APOBEC3B C1QBP CPSF1 CPSF7 DARS1 DDX1 DDX21 DDX3X DDX49 DHX36 DHX37 EDC4 EIF2AK2 EPRS1 FAM98A FUS GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 NOL6 NONO NUDT21 P3H1 PATL1 PDCD11 PLOD1 PRMT1 PTBP1 PTBP3 PUF60 PUM1 QARS1 RARS1 RBM14 RBM4 RBMS2 RTCB SF3B1 SF3B2 SF3B3 SFPQ STRBP SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TRIM71 UPF1 UTP20 YBX1 YBX2 YBX3 ZNF346	11 interacting genes: CDKN1A MIR1-1 MIR1-2 MIR100 MIR155 MIR15A MIR18B MIR25 MIR29A MIR29B1 MIRLET7F2
Entrez ID		406905	131405
HPRD ID			19029
Ensembl ID		ENSG00000284453	ENSG00000206557
Uniprot IDs			Q2Q1W2
PDB IDs			7QRX
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process MRNA Processing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Splicing Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process MRNA Binding Regulation Of RNA Splicing Nucleus Nucleoplasm Post-transcriptional Regulation Of Gene Expression Ribonucleoprotein Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Aminoacyl-tRNA Synthetase Multienzyme Complex MRNA 3'-UTR Binding MiRNA Binding Negative Regulation Of MRNA Metabolic Process Regulation Of Translation Spliceosomal Complex Catalytic Step 2 Spliceosome Regulation Of RNA Stability Regulation Of MRNA Processing Regulation Of Gene Expression Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Biosynthetic Process Cytoplasmic Stress Granule Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Catabolic Process P-body Negative Regulation Of Translation Negative Regulation Of MRNA Catabolic Process Regulation Of Primary Metabolic Process RNA Stabilization Regulation Of MRNA Stability TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Negative Regulation Of Macromolecule Metabolic Process TRNA Aminoacylation Nucleolus MRNA Stabilization Regulation Of Metabolic Process Positive Regulation Of Gene Expression TRNA Metabolic Process Negative Regulation Of Metabolic Process	RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Developmental Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Translation Negative Regulation Of Cell Cycle G1/S Phase Transition Extracellular Vesicle Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Circulating Fibrinogen Levels Regulation Of Mitotic Cell Cycle Phase Transition MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Amyloid-beta Formation Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Epithelial Cell Differentiation Regulation Of Gene Expression Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Translation Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Multicellular Organismal Process Regulation Of Amide Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Process Negative Regulation Of Developmental Growth MRNA Destabilization
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