MIR1-2 and P3H1

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR1-2	P3H1
Description		microRNA 1-2	prolyl 3-hydroxylase 1
Image		No pdb structure
GO Annotations	Cellular Component	RISC Complex	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane Extracellular Matrix Protein-containing Complex Extracellular Exosome
	Molecular Function		Iron Ion Binding Protein Binding Collagen Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Procollagen-proline 3-dioxygenase Activity L-ascorbic Acid Binding Metal Ion Binding Dioxygenase Activity
	Biological Process	MiRNA-mediated Post-transcriptional Gene Silencing	Protein Folding Negative Regulation Of Cell Population Proliferation Positive Regulation Of Neuron Projection Development Protein Hydroxylation Collagen Fibril Organization Regulation Of Ossification Negative Regulation Of Cell Growth Collagen Metabolic Process Regulation Of Protein Secretion Protein Stabilization Bone Development Negative Regulation Of Post-translational Protein Modification
Pathways			Collagen biosynthesis and modifying enzymes
Drugs			Ascorbic acid Proline
Diseases			Osteogenesis imperfecta
GWAS
Interacting Genes		78 interacting genes: ADARB1 APOBEC3B C1QBP CPSF1 CPSF7 DARS1 DDX1 DDX21 DDX3X DDX49 DHX36 DHX37 EDC4 EIF2AK2 EPRS1 FAM98A FUS GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 NOL6 NONO NUDT21 P3H1 PATL1 PDCD11 PLOD1 PRMT1 PTBP1 PTBP3 PUF60 PUM1 QARS1 RARS1 RBM14 RBM4 RBMS2 RTCB SF3B1 SF3B2 SF3B3 SFPQ STRBP SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TRIM71 UPF1 UTP20 YBX1 YBX2 YBX3 ZNF346	13 interacting genes: CDC42 MIR1-2 MIR107 MIR141 MIR18B MIR19A MIR19B1 MIR9-3 MIR92A1 MIRLET7A2 MIRLET7B MIRLET7I SLC2A4
Entrez ID		406905	64175
HPRD ID			11227
Ensembl ID		ENSG00000284453	ENSG00000117385
Uniprot IDs			Q32P28
PDB IDs			8K0E 8K0F 8K0I 8K0M 8K17 8KC9
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process MRNA Processing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Splicing Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process MRNA Binding Regulation Of RNA Splicing Nucleus Nucleoplasm Post-transcriptional Regulation Of Gene Expression Ribonucleoprotein Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Aminoacyl-tRNA Synthetase Multienzyme Complex MRNA 3'-UTR Binding MiRNA Binding Negative Regulation Of MRNA Metabolic Process Regulation Of Translation Spliceosomal Complex Catalytic Step 2 Spliceosome Regulation Of RNA Stability Regulation Of MRNA Processing Regulation Of Gene Expression Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Biosynthetic Process Cytoplasmic Stress Granule Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Catabolic Process P-body Negative Regulation Of Translation Negative Regulation Of MRNA Catabolic Process Regulation Of Primary Metabolic Process RNA Stabilization Regulation Of MRNA Stability TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Negative Regulation Of Macromolecule Metabolic Process TRNA Aminoacylation Nucleolus MRNA Stabilization Regulation Of Metabolic Process Positive Regulation Of Gene Expression TRNA Metabolic Process Negative Regulation Of Metabolic Process	RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Extracellular Vesicle MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Translation Negative Regulation Of Metabolic Process Negative Regulation Of Extracellular Matrix Organization MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition Regulation Of Gene Expression Negative Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Macromolecule Biosynthetic Process Regulation Of Sprouting Angiogenesis Negative Regulation Of Inflammatory Response Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Translation Regulation Of Extracellular Matrix Organization Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Programmed Necrotic Cell Death Negative Regulation Of Extracellular Matrix Assembly Regulation Of Matrix Metallopeptidase Secretion Cellular Response To Bacterial Lipopeptide Response To Bacterial Lipoprotein Negative Regulation Of Fibroblast Migration Regulation Of Macromolecule Metabolic Process Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death MRNA Destabilization Negative Regulation Of Defense Response Extracellular Space RNA Destabilization Negative Regulation Of Protein Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of MRNA Catabolic Process Regulation Of Angiogenesis Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Cell Migration Regulation Of Vasculature Development
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