KDM8 and ISY1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		KDM8	ISY1
Description		lysine demethylase 8	ISY1 spliceosome associated protein
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol	Prp19 Complex Nucleus Nucleoplasm Spliceosomal Complex U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome Post-mRNA Release Spliceosomal Complex Post-spliceosomal Complex
	Molecular Function	P53 Binding Chromatin Binding Endopeptidase Activity Aminopeptidase Activity Protein Binding Peptidase Activity Oxidoreductase Activity Hydrolase Activity Metal Ion Binding Dioxygenase Activity Histone H3K36 Demethylase Activity Peptidyl-arginine 3-dioxygenase Activity	RNA Binding Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle In Utero Embryonic Development Chromatin Organization Chromatin Remodeling Proteolysis Regulation Of Gene Expression Protein Destabilization Circadian Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Fibroblast Proliferation Rhythmic Process Regulation Of Signal Transduction By P53 Class Mediator	Generation Of Catalytic Spliceosome For Second Transesterification Step MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways		Protein hydroxylation	Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Asthma ( 31619474 31959851) Gut microbiota (bacterial taxa) ( 27723756) Night sleep phenotypes ( 27126917)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		8 interacting genes: DDIT4L H3C1 HEATR5B IFT20 ISY1 MEOX2 NUBPL PCYT2	9 interacting genes: CCNC EXOC8 FAM90A1 KDM8 LMO1 LMO2 MLH1 PTBP2 WBP4
Entrez ID		79831	57461
HPRD ID		07836	13834
Ensembl ID		ENSG00000155666	ENSG00000240682
Uniprot IDs		A0A0S2Z5P8 A0A0S2Z5T1 Q8N371	Q9ULR0
PDB IDs		3UYJ 4AAP 4GAZ 4GJY 4GJZ 4QU1 5FBJ 6AVS 6AX3 6F4M 6F4N 6F4O 6F4P 6F4Q 6F4R 6F4S 6F4T 6I9L 6I9M 6I9N 7DYT 7DYU 7DYV 7DYW 7DYX 7UQ3	5YZG 6FF7 6ZYM 7A5P 8C6J 8CH6 8I0W 8RO2 9FMD
Enriched GO Terms of Interacting Partners?
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