KDM8 and NUBPL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KDM8	NUBPL
Description		lysine demethylase 8	NUBP iron-sulfur cluster assembly factor, mitochondrial
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol	Mitochondrion Mitochondrial Matrix Plasma Membrane
	Molecular Function	P53 Binding Chromatin Binding Endopeptidase Activity Aminopeptidase Activity Protein Binding Peptidase Activity Oxidoreductase Activity Hydrolase Activity Metal Ion Binding Dioxygenase Activity Histone H3K36 Demethylase Activity Peptidyl-arginine 3-dioxygenase Activity	Nucleotide Binding Protein Binding ATP Binding Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding ATP-dependent FeS Chaperone Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle In Utero Embryonic Development Chromatin Organization Chromatin Remodeling Proteolysis Regulation Of Gene Expression Protein Destabilization Circadian Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Fibroblast Proliferation Rhythmic Process Regulation Of Signal Transduction By P53 Class Mediator	Mitochondrion Organization Iron-sulfur Cluster Assembly Mitochondrial Respiratory Chain Complex I Assembly
Pathways		Protein hydroxylation	Complex I biogenesis
Drugs
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Asthma ( 31619474 31959851) Gut microbiota (bacterial taxa) ( 27723756) Night sleep phenotypes ( 27126917)	Bitter alcoholic beverage consumption ( 31046077) Brain lesion load ( 19010793) Response to iloperidone treatment (QT prolongation) ( 18521091)
Interacting Genes		8 interacting genes: DDIT4L H3C1 HEATR5B IFT20 ISY1 MEOX2 NUBPL PCYT2	3 interacting genes: KDM8 MTUS2 NUBP2
Entrez ID		79831	80224
HPRD ID		07836	16600
Ensembl ID		ENSG00000155666	ENSG00000151413
Uniprot IDs		A0A0S2Z5P8 A0A0S2Z5T1 Q8N371	B3KSK2 B4DWB0 Q8TB37 X5D2R5
PDB IDs		3UYJ 4AAP 4GAZ 4GJY 4GJZ 4QU1 5FBJ 6AVS 6AX3 6F4M 6F4N 6F4O 6F4P 6F4Q 6F4R 6F4S 6F4T 6I9L 6I9M 6I9N 7DYT 7DYU 7DYV 7DYW 7DYX 7UQ3
Enriched GO Terms of Interacting Partners?			Peptidyl-arginine 3-dioxygenase Activity ATP-dependent FeS Chaperone Activity
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