PLTP and APOA2

Number of citations of the paper that reports this interaction (PubMedID 9469594)
0

Data Source:
HPRD (in vitro)

		PLTP	APOA2
Description		phospholipid transfer protein	apolipoprotein A2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus High-density Lipoprotein Particle	Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Lumen Cytosol Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Chylomicron Extracellular Exosome Blood Microparticle
	Molecular Function	Protein Binding High-density Lipoprotein Particle Binding Lipid Binding Phosphatidylethanolamine Binding Phosphatidylinositol Transfer Activity Diacylglycerol Binding Low-density Lipoprotein Particle Binding Phosphatidylcholine Binding Very-low-density Lipoprotein Particle Binding Phosphatidic Acid Binding Ceramide Binding Phospholipid Transfer Activity Ceramide Transfer Activity Phosphatidylcholine Transfer Activity Cholesterol Transfer Activity Diacylglyceride Transfer Activity Sphingomyelin Transfer Activity Phosphatidylglycerol Transfer Activity Cerebroside Transfer Activity Phosphatidylglycerol Binding Phosphatidylethanolamine Transfer Activity Phosphatidic Acid Transfer Activity	Signaling Receptor Binding Lipid Transporter Activity Protein Binding Phospholipid Binding High-density Lipoprotein Particle Binding Lipid Binding Cholesterol Binding Enzyme Binding Heat Shock Protein Binding Phosphatidylcholine Binding Apolipoprotein Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Receptor Ligand Activity Lipase Inhibitor Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Receptor Binding Cholesterol Transfer Activity
	Biological Process	Lipid Metabolic Process Lipid Transport Vitamin E Biosynthetic Process Positive Regulation Of Cholesterol Efflux Phospholipid Transport Sterol Transport Flagellated Sperm Motility High-density Lipoprotein Particle Remodeling Ceramide Transport Glycolipid Transport Intermembrane Lipid Transfer	Negative Regulation Of Cytokine Production Involved In Immune Response Triglyceride Metabolic Process Phosphatidylcholine Biosynthetic Process Lipid Transport Signal Transduction Cholesterol Metabolic Process Phospholipid Catabolic Process Response To Glucose Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Protein Oxidation Peptidyl-methionine Modification Regulation Of Intestinal Cholesterol Absorption Cholesterol Transport Regulation Of Protein Stability Negative Regulation Of Cholesterol Transport Positive Regulation Of Interleukin-8 Production Cholesterol Efflux Phospholipid Efflux Triglyceride-rich Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly High-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Cholesterol Homeostasis Reverse Cholesterol Transport Diacylglycerol Catabolic Process Positive Regulation Of Phagocytosis Protein Stabilization Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Negative Regulation Of Cholesterol Import Cellular Response To Lipoprotein Particle Stimulus Cellular Response To Amyloid-beta
Pathways			PPARA activates gene expression Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Retinoid metabolism and transport Retinoid metabolism and transport
Drugs			Zinc Copper Zinc acetate
Diseases			Familial amyloidosis
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Experiencing mood swings ( 29500382) Gut microbiota (functional units) ( 27694959) HDL cholesterol ( 19060906 28270201 25961943 24097068 20686565) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 33339817 29403010) Inflammatory bowel disease ( 23128233) LDL cholesterol levels ( 32203549) Lipid metabolism phenotypes ( 22286219 19936222) Low density lipoprotein cholesterol levels ( 32154731) Metabolite levels ( 22916037) Neurociticism ( 29500382) Pathological gambling ( 27315593) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels ( 30698716 29403010 28334899 32203549 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 25961943 24097068 20686565 19060906)
Interacting Genes		5 interacting genes: ABCA1 APOA1 APOA2 APOE CREB3	31 interacting genes: ABCA13 APOC1 APOD APOF AQP6 C4A CATSPER1 CIAO2A CREB3 CYBC1 GET1 GJA8 HSD17B13 KIR2DL3 LMNA MUC1 NAXE NDRG1 PANX1 PDZK1IP1 PLTP PSCA SCARB1 SLC7A1 SSMEM1 STOM TAB1 TMEM45A TMEM82 TREM2 VKORC1
Entrez ID		5360	336
HPRD ID		01399	00129
Ensembl ID		ENSG00000100979	ENSG00000158874
Uniprot IDs		P55058	P02652
PDB IDs
Enriched GO Terms of Interacting Partners?		High-density Lipoprotein Particle Assembly Phospholipid Efflux Reverse Cholesterol Transport Protein-lipid Complex Assembly Cholesterol Transfer Activity Plasma Lipoprotein Particle Assembly Cholesterol Efflux Lipoprotein Metabolic Process Cellular Response To Lipoprotein Particle Stimulus Lipoprotein Biosynthetic Process Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Cholesterol Transport High-density Lipoprotein Particle Binding Regulation Of Cdc42 Protein Signal Transduction Sterol Transport Chylomicron Phospholipid Transport Cholesterol Homeostasis Sterol Homeostasis Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Remodeling Cholesterol Metabolic Process Sterol Metabolic Process Signaling Receptor Binding High-density Lipoprotein Particle Lipid Transporter Activity Regulation Of Lipid Transport Organophosphate Ester Transport Positive Regulation Of Cholesterol Efflux Plasma Lipoprotein Particle Clearance Organic Hydroxy Compound Transport Lipid Homeostasis Positive Regulation Of Cholesterol Transport Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Peptidyl-methionine Modification High-density Lipoprotein Particle Receptor Binding Regulation Of Cholesterol Efflux Cholesterol Binding Steroid Metabolic Process Cellular Response To Amyloid-beta Regulation Of Transport Positive Regulation Of Phospholipid Efflux Apolipoprotein Receptor Binding Response To Amyloid-beta Alcohol Metabolic Process Positive Regulation Of Transport Lipid Transport	Regulation Of Cholesterol Transport Lipid Transport High-density Lipoprotein Particle Binding Low-density Lipoprotein Particle Binding Regulation Of Lipid Transport High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Regulation Of Phosphatidylcholine Catabolic Process Lipid Transporter Activity Sterol Transport Respiratory Burst After Phagocytosis Cholesterol Efflux Plasma Lipoprotein Particle Remodeling Detection Of Lipopolysaccharide Apolipoprotein A-I Binding Very-low-density Lipoprotein Particle Binding Positive Regulation Of Cholesterol Transport Protein-containing Complex Remodeling Regulation Of Phospholipid Catabolic Process Regulation Of Cholesterol Efflux Monoatomic Anion Channel Activity Positive Regulation Of Apoptotic Cell Clearance Respiratory Burst Involved In Defense Response Organophosphate Ester Transport Regulation Of Phosphatidylcholine Metabolic Process Regulation Of Apoptotic Cell Clearance Organic Hydroxy Compound Transport Cholesterol Transport Endoplasmic Reticulum Regulation Of Endocytosis Detection Of Molecule Of Bacterial Origin Phagocytosis, Recognition Kinase Activator Activity Regulation Of Lipid Metabolic Process Phosphatidylethanolamine Binding Regulation Of Transport Carbohydrate Derivative Transport Apolipoprotein Binding Ceramide Transport Positive Regulation Of Lipid Transport Membrane Phospholipid Transport Gap Junction Channel Activity Respiratory Burst Regulation Of Phagocytosis Gap Junction Plasma Lipoprotein Particle Clearance Positive Regulation Of Cholesterol Efflux Cholesterol Metabolic Process Sterol Metabolic Process
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