PLTP and APOA2

Number of citations of the paper that reports this interaction (PMID 9469594)
7

Data Source:
HPRD (in vitro)

		PLTP	APOA2
Gene Name		phospholipid transfer protein	apolipoprotein A-II
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Early Endosome Endoplasmic Reticulum Lumen Cytosol Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Chylomicron Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Lipid Binding	Lipid Transporter Activity Protein Binding Phospholipid Binding High-density Lipoprotein Particle Binding Lipid Binding Cholesterol Binding Cholesterol Transporter Activity Phosphatidylcholine Binding Apolipoprotein Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Lipase Inhibitor Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Receptor Binding
	Biological Process	Lipid Metabolic Process Lipid Transport Vitamin E Biosynthetic Process Sperm Motility	Retinoid Metabolic Process Acute Inflammatory Response Negative Regulation Of Cytokine Secretion Involved In Immune Response Protein Folding Triglyceride Metabolic Process Phosphatidylcholine Biosynthetic Process Phototransduction, Visible Light Cholesterol Metabolic Process Phospholipid Catabolic Process Response To Glucose Positive Regulation Of Cholesterol Esterification Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Viral Process Protein Oxidation Peptidyl-methionine Modification Regulation Of Intestinal Cholesterol Absorption Organ Regeneration Regulation Of Protein Stability Negative Regulation Of Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Triglyceride-rich Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly High-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Response To Drug Cholesterol Homeostasis Positive Regulation Of Catalytic Activity Response To Estrogen Reverse Cholesterol Transport Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Diacylglycerol Catabolic Process Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Response To Glucocorticoid Negative Regulation Of Lipase Activity Negative Regulation Of Cholesterol Import Negative Regulation Of Cholesterol Transporter Activity
Pathways			Lipoprotein metabolism PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Visual phototransduction Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Lipid digestion, mobilization, and transport Diseases associated with visual transduction Retinoid metabolism and transport
Drugs
Diseases
GWAS		HDL cholesterol ( 19060906 20686565) Inflammatory bowel disease ( 23128233) Lipid metabolism phenotypes ( 22286219 19936222) Metabolite levels ( 22916037) Triglycerides ( 19060906 20686565)
Protein-Protein Interactions		4 interactors: ABCA1 APOA1 APOA2 APOE	11 interactors: ABCA13 APOA1 APOA1BP APOC1 APOD APOF C4A CATSPER1 PLTP SCARB1 VKORC1
Entrez ID		5360	336
HPRD ID		01399	00129
Ensembl ID		ENSG00000100979	ENSG00000158874
Uniprot IDs		B3KUE5 B4DDD5 P55058	P02652
PDB IDs			1L6L 2OU1
Enriched GO Terms of Interacting Partners?		High-density Lipoprotein Particle Assembly Phospholipid Efflux Reverse Cholesterol Transport Protein-lipid Complex Assembly Cholesterol Efflux Regulation Of Cholesterol Transport High-density Lipoprotein Particle Clearance Regulation Of Plasma Lipoprotein Particle Levels Cholesterol Transport Sterol Transport Positive Regulation Of Cholesterol Esterification Cholesterol Homeostasis Sterol Homeostasis Regulation Of Cholesterol Esterification Regulation Of Lipid Transport Phospholipid Transport Cholesterol Metabolic Process Lipid Homeostasis Sterol Metabolic Process High-density Lipoprotein Particle Remodeling Lipoprotein Metabolic Process Plasma Lipoprotein Particle Remodeling Positive Regulation Of Steroid Metabolic Process Regulation Of Cdc42 Protein Signal Transduction Plasma Lipoprotein Particle Clearance Steroid Metabolic Process Lipid Transport Anion Homeostasis Lipid Localization Alcohol Metabolic Process Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Organic Anion Transport Phototransduction, Visible Light Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Regulation Of Steroid Metabolic Process Detection Of Light Stimulus Regulation Of Intestinal Cholesterol Absorption Protein Oxidation Lipoprotein Biosynthetic Process Negative Regulation Of Cytokine Secretion Involved In Immune Response Isoprenoid Metabolic Process Anion Transport Phospholipid Homeostasis Peptidyl-methionine Modification Peripheral Nervous System Axon Regeneration Triglyceride-rich Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling	Cholesterol Efflux Lipid Transport Lipid Localization Sterol Transport Cholesterol Transport High-density Lipoprotein Particle Remodeling Cholesterol Metabolic Process Plasma Lipoprotein Particle Remodeling Sterol Metabolic Process Plasma Lipoprotein Particle Clearance Cholesterol Import Regulation Of Phosphatidylcholine Catabolic Process Regulation Of Lipid Catabolic Process High-density Lipoprotein Particle Clearance Regulation Of Plasma Lipoprotein Particle Levels Steroid Metabolic Process Positive Regulation Of Cholesterol Esterification Regulation Of Lipid Metabolic Process Lipid Metabolic Process Phospholipid Transport Regulation Of Cholesterol Esterification Peripheral Nervous System Axon Regeneration Phospholipid Efflux Alcohol Metabolic Process Small Molecule Metabolic Process Protein-lipid Complex Assembly Endothelial Cell Proliferation Regulation Of Lipid Biosynthetic Process Reverse Cholesterol Transport Negative Regulation Of Lipase Activity Lipoprotein Metabolic Process Positive Regulation Of Steroid Metabolic Process Regulation Of Endocytosis Blood Vessel Endothelial Cell Migration Regulation Of Fatty Acid Biosynthetic Process Regulation Of Triglyceride Metabolic Process Wound Healing Triglyceride Homeostasis Acylglycerol Homeostasis Regulation Of Cholesterol Transport Axon Regeneration Response To Wounding Neuron Projection Regeneration Regulation Of Inflammatory Response Sperm Motility Transport Positive Regulation Of Lipid Biosynthetic Process Regulation Of Phagocytosis Response To Axon Injury Negative Regulation Of Phosphatidylcholine Catabolic Process
Tagcloud ?		abca1 abcg5 abcg8 atorvastatin causal challenging chow excised fads1 gwas hfd hypertensive list loci lpl madd nominally nr1h3 orthologs overlapped pcsk9 qpcr qtl responded spontaneously stac3 staged suggestive timd4	atp1 craniorachischisis d1hun13 d1hun14 d1mit110 d1mit111 d1mit112 d1mit114 d1mit145 d1mit146 d1mit147 d1mit148 d1mit149 d1mit15 d1mit205 d1mit270 d1mit36 d1mit62 eph1 fcer1 fcgr2 hlix1 intergene interlocus looptail spna1 spretus sslp swr
Tagcloud (Difference) ?		abca1 abcg5 abcg8 atorvastatin causal challenging chow excised fads1 gwas hfd hypertensive list loci lpl madd nominally nr1h3 orthologs overlapped pcsk9 qpcr qtl responded spontaneously stac3 staged suggestive timd4	atp1 craniorachischisis d1hun13 d1hun14 d1mit110 d1mit111 d1mit112 d1mit114 d1mit145 d1mit146 d1mit147 d1mit148 d1mit149 d1mit15 d1mit205 d1mit270 d1mit36 d1mit62 eph1 fcer1 fcgr2 hlix1 intergene interlocus looptail spna1 spretus sslp swr
Tagcloud (Intersection) ?