PLTP

Description		phospholipid transfer protein
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus High-density Lipoprotein Particle
	Molecular Function	Protein Binding High-density Lipoprotein Particle Binding Lipid Binding Phosphatidylethanolamine Binding Phosphatidylinositol Transfer Activity Diacylglycerol Binding Low-density Lipoprotein Particle Binding Phosphatidylcholine Binding Very-low-density Lipoprotein Particle Binding Phosphatidic Acid Binding Ceramide Binding Phospholipid Transfer Activity Ceramide Transfer Activity Phosphatidylcholine Transfer Activity Cholesterol Transfer Activity Diacylglyceride Transfer Activity Sphingomyelin Transfer Activity Phosphatidylglycerol Transfer Activity Cerebroside Transfer Activity Phosphatidylglycerol Binding Phosphatidylethanolamine Transfer Activity Phosphatidic Acid Transfer Activity
	Biological Process	Lipid Metabolic Process Lipid Transport Vitamin E Biosynthetic Process Positive Regulation Of Cholesterol Efflux Phospholipid Transport Sterol Transport Flagellated Sperm Motility High-density Lipoprotein Particle Remodeling Ceramide Transport Glycolipid Transport Intermembrane Lipid Transfer
Pathways
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Experiencing mood swings ( 29500382) Gut microbiota (functional units) ( 27694959) HDL cholesterol ( 19060906 28270201 25961943 24097068 20686565) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 33339817 29403010) Inflammatory bowel disease ( 23128233) LDL cholesterol levels ( 32203549) Lipid metabolism phenotypes ( 22286219 19936222) Low density lipoprotein cholesterol levels ( 32154731) Metabolite levels ( 22916037) Neurociticism ( 29500382) Pathological gambling ( 27315593) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels ( 30698716 29403010 28334899 32203549 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 25961943 24097068 20686565 19060906)
Novel Interacting Genes		1 novel interacting genes: SRC
Interacting Genes		5 interacting genes: ABCA1 APOA1 APOA2 APOE CREB3
Entrez ID		5360
HPRD ID		01399
Ensembl ID		ENSG00000100979
Uniprot IDs		P55058
PDB IDs
Enriched GO Terms of Interacting Partners?		High-density Lipoprotein Particle Assembly Phospholipid Efflux Reverse Cholesterol Transport Protein-lipid Complex Assembly Cholesterol Transfer Activity Plasma Lipoprotein Particle Assembly Cholesterol Efflux Lipoprotein Metabolic Process Cellular Response To Lipoprotein Particle Stimulus Lipoprotein Biosynthetic Process Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Cholesterol Transport High-density Lipoprotein Particle Binding Regulation Of Cdc42 Protein Signal Transduction Sterol Transport Chylomicron Phospholipid Transport Cholesterol Homeostasis Sterol Homeostasis Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Remodeling Cholesterol Metabolic Process Sterol Metabolic Process Signaling Receptor Binding High-density Lipoprotein Particle Lipid Transporter Activity Regulation Of Lipid Transport Organophosphate Ester Transport Positive Regulation Of Cholesterol Efflux Plasma Lipoprotein Particle Clearance Organic Hydroxy Compound Transport Lipid Homeostasis Positive Regulation Of Cholesterol Transport Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Peptidyl-methionine Modification High-density Lipoprotein Particle Receptor Binding Regulation Of Cholesterol Efflux Cholesterol Binding Steroid Metabolic Process Cellular Response To Amyloid-beta Regulation Of Transport Positive Regulation Of Phospholipid Efflux Apolipoprotein Receptor Binding Response To Amyloid-beta Alcohol Metabolic Process Positive Regulation Of Transport Lipid Transport
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