PLOD1 and USP4

Number of citations of the paper that reports this interaction (PMID 23022198)
1

Data Source:
BioGRID (two hybrid)

		PLOD1	USP4
Gene Name		procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1	ubiquitin specific peptidase 4 (proto-oncogene)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Lysosome Plasma Membrane
	Molecular Function	Iron Ion Binding Procollagen-lysine 5-dioxygenase Activity L-ascorbic Acid Binding Protein Homodimerization Activity	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Adenosine Receptor Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Response To Hypoxia Cellular Protein Modification Process Epidermis Development Extracellular Matrix Organization Hydroxylysine Biosynthetic Process Oxidation-reduction Process	Spliceosomal Tri-snRNP Complex Assembly Protein Deubiquitination Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Localization To Cell Surface Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process
Pathways		Collagen formation Collagen biosynthesis and modifying enzymes
Drugs		Vitamin C Succinic acid
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		1 interactors: USP4	46 interactors: AKT1 ANXA7 ASS1 ATP1B1 ATP1B3 BRAP CDKN1A FAM96B HUWE1 IGKV2D-29 LAMA5 LGALS1 NLK NOLC1 NPC2 PCNA PDK1 PGM1 PLA2G2A PLOD1 PPIA PRPF3 PSAP PSMA6 PSMC5 PSMD11 RB1 RBL1 RBL2 RCC1 SART3 SMN1 TCF4 TGFBR1 TK1 TP53BP2 TRAF2 TRAF6 TRIM21 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28
Entrez ID		5351	7375
HPRD ID		01086	04598
Ensembl ID		ENSG00000083444	ENSG00000114316
Uniprot IDs		B4DR87 Q02809	Q08AK7 Q13107
PDB IDs			2Y6E
Enriched GO Terms of Interacting Partners?		Spliceosomal Tri-snRNP Complex Assembly Protein Localization To Cell Surface Spliceosomal SnRNP Assembly Negative Regulation Of Protein Ubiquitination Protein Deubiquitination Protein Modification By Small Protein Removal Regulation Of Protein Stability Ribonucleoprotein Complex Assembly Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Ubiquitination MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Apoptotic Process Cell Cycle Response To Stress Programmed Cell Death Cell Death Death Response To Stimulus Protein Polyubiquitination Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Signal Transduction By P53 Class Mediator Positive Regulation Of Cell Cycle Protein Ubiquitination Mitotic Cell Cycle Protein Catabolic Process Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Immune System Process Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Proteolysis Cell Cycle Process Regulation Of Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of Proteolysis Regulation Of Lipid Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Negative Regulation Of Transferase Activity Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of Catalytic Activity Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Intracellular Signal Transduction Negative Regulation Of Cell Cycle Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Cell Cycle Checkpoint Cellular Response To Stimulus Mitotic G1 DNA Damage Checkpoint Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		activates biogenesis biopsies breast collagen constituent ecm encoding fibrillar hif hydroxylases hypoxia hypoxic inducible intratumoral lungs lymph lysyl majority matrix metastasis metastatic mortality nodes plod2 procollagen stiffness therapies treat	1beta adaptor associates deubiquitinase deubiquitinates deubiquitination ectopic ikappabalpha importantly incompletely insight interact interacts kappab kappabalpha negatively nf polyubiquitination protease reporter signalling tnfalpha traf traf2 traf3 traf6 ubiquitin uncovers
Tagcloud (Difference) ?		activates biogenesis biopsies breast collagen constituent ecm encoding fibrillar hif hydroxylases hypoxia hypoxic inducible intratumoral lungs lymph lysyl majority matrix metastasis metastatic mortality nodes plod2 procollagen stiffness therapies treat	1beta adaptor associates deubiquitinase deubiquitinates deubiquitination ectopic ikappabalpha importantly incompletely insight interact interacts kappab kappabalpha negatively nf polyubiquitination protease reporter signalling tnfalpha traf traf2 traf3 traf6 ubiquitin uncovers
Tagcloud (Intersection) ?