GCHFR and GCH1

Number of citations of the paper that reports this interaction (PMID 8702680)
16

Data Source:
HPRD (in vitro)

		GCHFR	GCH1
Gene Name		GTP cyclohydrolase I feedback regulator	GTP cyclohydrolase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Dendrite Nuclear Membrane Melanosome Protein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein Complex
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Amino Acid Binding GTP-dependent Protein Binding GTP Cyclohydrolase Binding	GTP Cyclohydrolase I Activity Calcium Ion Binding Protein Binding GTP Binding Zinc Ion Binding GTP-dependent Protein Binding Protein Homodimerization Activity Coenzyme Binding
	Biological Process	Nitric Oxide Biosynthetic Process Negative Regulation Of Biosynthetic Process Neurotransmitter Metabolic Process Negative Regulation Of GTP Cyclohydrolase I Activity Small Molecule Metabolic Process Nitric Oxide Metabolic Process Regulation Of Nitric-oxide Synthase Activity Protein Heterooligomerization	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Metabolic Process Regulation Of Blood Pressure Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Interferon-gamma Response To Tumor Necrosis Factor 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Vasodilation Dopamine Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Small Molecule Metabolic Process Negative Regulation Of Blood Pressure Nitric Oxide Metabolic Process Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Nitric-oxide Synthase Activity Protein Homooligomerization Protein Heterooligomerization
Pathways		Metabolism of nitric oxide eNOS activation and regulation Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	Metabolism of nitric oxide eNOS activation and regulation Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs			Guanine
Diseases
GWAS			Obesity-related traits ( 23251661) Rheumatoid arthritis ( 22446963)
Protein-Protein Interactions		1 interactors: GCH1	13 interactors: AHSA1 ATP1B1 CDC37 CNRIP1 GCHFR GIT2 HSPA8 RAB26 RLF RPH3A SH3GL2 SP3 YWHAZ
Entrez ID		2644	2643
HPRD ID		03895	02573
Ensembl ID		ENSG00000137880	ENSG00000131979
Uniprot IDs		P30047	P30793 Q8IZH9
PDB IDs			1FB1
Enriched GO Terms of Interacting Partners?		7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Regulation Of Lung Blood Pressure Dihydrobiopterin Metabolic Process Tetrahydrofolate Biosynthetic Process Tetrahydrobiopterin Biosynthetic Process Dopamine Biosynthetic Process Nitric Oxide Biosynthetic Process Neuromuscular Process Controlling Posture Positive Regulation Of Nitric-oxide Synthase Activity Catecholamine Biosynthetic Process Tetrahydrofolate Metabolic Process Positive Regulation Of Monooxygenase Activity Nitric Oxide Metabolic Process Dopamine Metabolic Process Folic Acid-containing Compound Biosynthetic Process Reactive Nitrogen Species Metabolic Process Vasodilation Pteridine-containing Compound Biosynthetic Process Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Oxidoreductase Activity Response To Pain Catecholamine Metabolic Process Folic Acid-containing Compound Metabolic Process Negative Regulation Of Blood Pressure Pteridine-containing Compound Metabolic Process Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Oxidoreductase Activity Multicellular Organismal Response To Stress Phenol-containing Compound Metabolic Process Reactive Oxygen Species Metabolic Process Response To Tumor Necrosis Factor Neuromuscular Process Cellular Amino Acid Biosynthetic Process Protein Heterooligomerization Coenzyme Biosynthetic Process Response To Interferon-gamma Regulation Of Blood Pressure Cellular Modified Amino Acid Metabolic Process Cellular Amide Metabolic Process Protein Homooligomerization Alpha-amino Acid Metabolic Process Blood Circulation Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Cofactor Metabolic Process Protein Oligomerization Cellular Amino Acid Metabolic Process Response To Bacterium Response To Cytokine	Intracellular Transport Post-Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Membrane Organization Intracellular Protein Transport Cellular Localization Positive Regulation Of ATPase Activity Regulation Of ATPase Activity Regulated Secretory Pathway Golgi Vesicle Transport Cellular Protein Localization Protein Transport Establishment Of Protein Localization Negative Regulation Of Fibril Organization Negative Regulation Of GTP Cyclohydrolase I Activity Establishment Of Protein Localization To Plasma Membrane Cell-cell Signaling Protein Stabilization Positive Regulation Of Calcium:sodium Antiporter Activity Endomembrane System Organization Positive Regulation Of Potassium Ion Import Regulation Of Fibril Organization Protein Localization Secretion By Cell Golgi Reassembly Positive Regulation Of Sodium Ion Export From Cell Regulation Of Protein Stability Regulation Of Neurotransmitter Levels Regulation Of Metabolic Process Protein Transport Into Plasma Membrane Raft Clathrin Coat Disassembly Protein Localization To Plasma Membrane Protein Localization To Plasma Membrane Raft Histamine Secretion By Mast Cell Sodium Ion Export From Cell Establishment Of Golgi Localization Secretion Positive Regulation Of Metabolic Process Sodium Ion Export Golgi Inheritance Regulation Of Catalytic Activity Cellular Potassium Ion Homeostasis Vesicle-mediated Transport Histamine Secretion Transport Protein Transport Into Membrane Raft Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Plasma Membrane Organization Embryonic Process Involved In Female Pregnancy
Tagcloud ?			allele bodily carriers catechol comt confers copies cyclohydrolase disadvantageous enzymatic epistatic esr1 guanosine met methylenetetrahydrofolate minor mthfr musculoskeletal normalized poorer reductase rs10483639 rs3020377 rs4680 temporomandibular thresholds tmd triphosphate val
Tagcloud (Difference) ?			allele bodily carriers catechol comt confers copies cyclohydrolase disadvantageous enzymatic epistatic esr1 guanosine met methylenetetrahydrofolate minor mthfr musculoskeletal normalized poorer reductase rs10483639 rs3020377 rs4680 temporomandibular thresholds tmd triphosphate val
Tagcloud (Intersection) ?