GCHFR

Description		GTP cyclohydrolase I feedback regulator
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Dendrite Nuclear Membrane Melanosome
	Molecular Function	Enzyme Inhibitor Activity Protein Binding GTP Cyclohydrolase Binding GTP Cyclohydrolase I Regulator Activity
	Biological Process	Negative Regulation Of Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Small Molecule Metabolic Process
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs
Diseases
GWAS		Anxiety and stress-related disorders ( 31116379) Malaria ( 31844061) Triglycerides ( 30275531)
Novel Interacting Genes		1 novel interacting genes: PLCB2
Interacting Genes		1 interacting genes: GCH1
Entrez ID		2644
HPRD ID		03895
Ensembl ID		ENSG00000137880
Uniprot IDs		P30047
PDB IDs		6Z80 6Z85 7ACC 7AL9 7ALA 7ALB 7ALC 7ALQ
Enriched GO Terms of Interacting Partners?		GTP Cyclohydrolase I Activity G-protein Beta/gamma-subunit Complex Regulation Of Lung Blood Pressure Positive Regulation Of Nitric-oxide Synthase Activity Tetrahydrofolate Biosynthetic Process Regulation Of Removal Of Superoxide Radicals Regulation Of Nitric-oxide Synthase Activity Tetrahydrobiopterin Biosynthetic Process Phosphatidylinositol Phospholipase C Activity Sensory Perception Of Bitter Taste Folic Acid-containing Compound Biosynthetic Process Tetrahydrobiopterin Metabolic Process Dopamine Biosynthetic Process Regulation Of Response To Reactive Oxygen Species Neuron Projection Terminus Response To Pain Catecholamine Biosynthetic Process Regulation Of Cellular Response To Oxidative Stress Mitogen-activated Protein Kinase Binding Pteridine-containing Compound Biosynthetic Process Tetrahydrofolate Metabolic Process Nitric Oxide Biosynthetic Process Nervous System Process Regulation Of Oxidoreductase Activity Neuromuscular Process Controlling Posture Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Neuronal Dense Core Vesicle Phospholipase C Activity Phosphatidylinositol-mediated Signaling G-protein Beta/gamma-subunit Complex Binding Detection Of Chemical Stimulus Involved In Sensory Perception Of Taste Folic Acid-containing Compound Metabolic Process Regulation Of Response To Oxidative Stress Nitric Oxide Metabolic Process Regulation Of Superoxide Metabolic Process Reactive Nitrogen Species Metabolic Process Diol Metabolic Process Dopamine Metabolic Process Positive Regulation Of Heart Rate Pteridine-containing Compound Metabolic Process Sensory Perception Of Taste Biogenic Amine Biosynthetic Process Amine Biosynthetic Process Positive Regulation Of Heart Contraction Catecholamine Metabolic Process Phosphoric Diester Hydrolase Activity Negative Regulation Of Sequestering Of Calcium Ion Release Of Sequestered Calcium Ion Into Cytosol System Process
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