PFKFB3 and OTUD4

Number of citations of the paper that reports this interaction (PubMedID 37162556)
50

Data Source:
BioGRID (pull down)

		PFKFB3	OTUD4
Description		6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	OTU deubiquitinase 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Catalytic Activity 6-phosphofructo-2-kinase Activity Fructose-2,6-bisphosphate 2-phosphatase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Hydrolase Activity	RNA Binding Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Molecular Adaptor Activity K63-linked Deubiquitinase Activity
	Biological Process	Fructose Metabolic Process Fructose 2,6-bisphosphate Metabolic Process Gluconeogenesis Glycolytic Process Apoptotic Process Glial Cell Differentiation Carbohydrate Phosphorylation Motor Behavior	Immune System Process DNA Alkylation Repair Proteolysis Negative Regulation Of Toll-like Receptor Signaling Pathway Protein K11-linked Deubiquitination Protein K27-linked Ubiquitination Innate Immune Response Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Antiviral Innate Immune Response Regulation Of Protein K48-linked Deubiquitination Negative Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Asthma ( 31619474 31959851) Asthma (childhood onset) ( 31036433) Celiac disease ( 22057235 24999842) Crohn's disease ( 28067908) Latent autoimmune diabetes ( 30254083) Metabolite levels ( 23823483) Obesity (extreme) ( 31888951) Plasma anti-thyroid peroxidase levels ( 29678681) Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) ( 25117820) Selective IgA deficiency ( 27723758) Western dietary pattern ( 28644415)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Heel bone mineral density ( 28869591 30598549) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172 25673412) Lung function (FEV1) ( 30061609) Malaria ( 31844061) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 31628463) Red blood cell count ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		4 interacting genes: CTNNB1 GCK OTUD4 PFKFB1	12 interacting genes: ALKBH3 EXOSC8 MAVS PFKFB3 REL STAT1 TCF4 UBC USP7 VDR ZBTB7A ZNF655
Entrez ID		5209	54726
HPRD ID		05612	11033
Ensembl ID		ENSG00000170525	ENSG00000164164
Uniprot IDs		A0A1W2PR17 B7Z8A0 Q16875	Q01804
PDB IDs		2AXN 2DWO 2DWP 2I1V 3QPU 3QPV 3QPW 4D4J 4D4K 4D4L 4D4M 4MA4 5AJV 5AJW 5AJX 5AJY 5AJZ 5AK0 6ETJ 6HVH 6HVI 6HVJ 6IBX 6IBY 6IBZ 6IC0
Enriched GO Terms of Interacting Partners?		Nephron Tubule Formation Histone Methyltransferase Binding Nucleobase-containing Compound Metabolic Process Regulation Of Nephron Tubule Epithelial Cell Differentiation Mesenchymal To Epithelial Transition Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Carbohydrate Phosphorylation Embryonic Epithelial Tube Formation Epithelial Tube Formation Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Morphogenesis Of An Epithelium Thymus Development Cell Fate Determination T Cell Differentiation In Thymus ADP Catabolic Process ADP Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Regulation Of Glycolytic Process Glycolytic Process Ribonucleoside Diphosphate Catabolic Process DNA-templated Transcription Regulation Of Animal Organ Morphogenesis Glial Cell Fate Determination Regulation Of Morphogenesis Of An Epithelium Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Regulation Of Cellular Response To X-ray Negative Regulation Of Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation Type IV Hypersensitivity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation Negative Regulation Of Cell Proliferation Involved In Mesonephros Development Pyruvate Metabolic Process Purine Ribonucleotide Catabolic Process Regulation Of Carbohydrate Catabolic Process Regulation Of ATP Metabolic Process Ribonucleoside Diphosphate Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Nucleoside Diphosphate Metabolic Process Purine Nucleotide Catabolic Process Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Beta-catenin-ICAT Complex Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Canonical Wnt Signaling Pathway Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Epithelial Tube Morphogenesis	Regulation Of Macromolecule Biosynthetic Process Regulation Of Type I Interferon Production Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Interferon-alpha Production Histone Acetyltransferase Binding DNA Alkylation Repair Cytosol Negative Regulation Of Macromolecule Biosynthetic Process Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Interferon-beta Production Brain Renin-angiotensin System TORC1 Signaling Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Type I Interferon-mediated Signaling Pathway Regulation Of Defense Response To Virus Negative Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Interferon-mediated Signaling Pathway Regulation Of Defense Response To Virus By Host Transcription Corepressor Binding Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Negative Regulation Of Phosphate Transmembrane Transport Calcitriol Binding MRNA Transcription Nuclear Receptor-mediated Bile Acid Signaling Pathway Bile Acid Nuclear Receptor Activity Lithocholic Acid Binding Regulation Of Peroxisome Organization Positive Regulation Of IP-10 Production MRNA N1-methyladenosine Dioxygenase Activity Nucleobase-containing Compound Metabolic Process Nucleoplasm 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex 6-phosphofructo-2-kinase Activity Regulation Of DNA-templated Transcription Cytoplasm Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Intracellular Signal Transduction Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II NF-kappaB Complex Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Metabolic Process
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