PFKFB3

Description		6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
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GO Annotations	Cellular Component	Nucleoplasm Cytosol 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex
	Molecular Function	Nucleotide Binding Catalytic Activity 6-phosphofructo-2-kinase Activity Fructose-2,6-bisphosphate 2-phosphatase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Hydrolase Activity
	Biological Process	Fructose Metabolic Process Fructose 2,6-bisphosphate Metabolic Process Gluconeogenesis Glycolytic Process Apoptotic Process Glial Cell Differentiation Carbohydrate Phosphorylation Motor Behavior
Pathways		Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Asthma ( 31619474 31959851) Asthma (childhood onset) ( 31036433) Celiac disease ( 22057235 24999842) Crohn's disease ( 28067908) Latent autoimmune diabetes ( 30254083) Metabolite levels ( 23823483) Obesity (extreme) ( 31888951) Plasma anti-thyroid peroxidase levels ( 29678681) Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) ( 25117820) Selective IgA deficiency ( 27723758) Western dietary pattern ( 28644415)
Novel Interacting Genes		2 novel interacting genes: GATA3 THAP1
Interacting Genes		4 interacting genes: CTNNB1 GCK OTUD4 PFKFB1
Entrez ID		5209
HPRD ID		05612
Ensembl ID		ENSG00000170525
Uniprot IDs		A0A1W2PR17 B7Z8A0 Q16875
PDB IDs		2AXN 2DWO 2DWP 2I1V 3QPU 3QPV 3QPW 4D4J 4D4K 4D4L 4D4M 4MA4 5AJV 5AJW 5AJX 5AJY 5AJZ 5AK0 6ETJ 6HVH 6HVI 6HVJ 6IBX 6IBY 6IBZ 6IC0
Enriched GO Terms of Interacting Partners?		Nephron Tubule Formation Histone Methyltransferase Binding Nucleobase-containing Compound Metabolic Process Regulation Of Nephron Tubule Epithelial Cell Differentiation Mesenchymal To Epithelial Transition Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Carbohydrate Phosphorylation Embryonic Epithelial Tube Formation Epithelial Tube Formation Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Morphogenesis Of An Epithelium Thymus Development Cell Fate Determination T Cell Differentiation In Thymus ADP Catabolic Process ADP Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Regulation Of Glycolytic Process Glycolytic Process Ribonucleoside Diphosphate Catabolic Process DNA-templated Transcription Regulation Of Animal Organ Morphogenesis Glial Cell Fate Determination Regulation Of Morphogenesis Of An Epithelium Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Regulation Of Cellular Response To X-ray Negative Regulation Of Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation Type IV Hypersensitivity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation Negative Regulation Of Cell Proliferation Involved In Mesonephros Development Pyruvate Metabolic Process Purine Ribonucleotide Catabolic Process Regulation Of Carbohydrate Catabolic Process Regulation Of ATP Metabolic Process Ribonucleoside Diphosphate Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Nucleoside Diphosphate Metabolic Process Purine Nucleotide Catabolic Process Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Beta-catenin-ICAT Complex Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Canonical Wnt Signaling Pathway Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Epithelial Tube Morphogenesis
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