CFP and CFB

Number of citations of the paper that reports this interaction (PMID 3140783)
6

Data Source:
HPRD (in vitro)

		CFP	CFB
Gene Name		complement factor properdin	complement factor B
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix	Extracellular Region Extracellular Space Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function		Complement Binding Serine-type Endopeptidase Activity
	Biological Process	Protein O-linked Glycosylation Immune Response Complement Activation Complement Activation, Alternative Pathway Regulation Of Complement Activation Protein O-linked Fucosylation Defense Response To Bacterium Post-translational Protein Modification Cellular Protein Metabolic Process Innate Immune Response	Proteolysis Complement Activation Complement Activation, Alternative Pathway Regulation Of Complement Activation Innate Immune Response
Pathways		Alternative complement activation Regulation of Complement cascade Post-translational protein modification Complement cascade Activation of C3 and C5 O-glycosylation of TSR domain-containing proteins Initial triggering of complement Innate Immune System O-linked glycosylation	Alternative complement activation Regulation of Complement cascade Complement cascade Activation of C3 and C5 Initial triggering of complement Innate Immune System
Drugs			4-Guanidinobenzoic Acid Diisopropylphosphono Group
Diseases
GWAS			Age-related macular degeneration ( 20385819 20385826 22694956 23577725 23455636 21665990) Age-related macular degeneration (CNV) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (GA) ( 22705344) Hematology traits ( 23263863) Prostate cancer ( 23535732)
Protein-Protein Interactions		3 interactors: C3 CFB MTOR	4 interactors: C3 CFP LAMC3 RPA2
Entrez ID		5199	629
HPRD ID		02308	00718
Ensembl ID		ENSG00000126759	ENSG00000243649
Uniprot IDs		P27918	P00751
PDB IDs		1W0R 1W0S	1DLE 1Q0P 1RRK 1RS0 1RTK 2OK5 2WIN 2XWB 2XWJ 3HRZ 3HS0
Enriched GO Terms of Interacting Partners?		Complement Activation, Alternative Pathway Regulation Of Complement Activation Regulation Of Humoral Immune Response Regulation Of Acute Inflammatory Response Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Lipid Biosynthetic Process Complement Activation Regulation Of Carbohydrate Utilization Protein Activation Cascade Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Type IIa Hypersensitivity Humoral Immune Response Regulation Of Inflammatory Response Regulation Of Lipid Metabolic Process Positive Regulation Of Activation Of Membrane Attack Complex Immune System Process Positive Regulation Of Hypersensitivity Regulation Of Protein Metabolic Process Regulation Of Protein Processing Negative Regulation Of NFAT Protein Import Into Nucleus Positive Regulation Of Apoptotic Cell Clearance Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Transcription From RNA Polymerase III Promoter Regulation Of Apoptotic Cell Clearance Negative Regulation Of Macroautophagy Positive Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Cell Size Positive Regulation Of Humoral Immune Response Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Lamellipodium Organization Positive Regulation Of Immune Response Regulation Of Response To Food Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Protein Processing Regulation Of Triglyceride Biosynthetic Process Regulation Of Rac GTPase Activity TOR Signaling Positive Regulation Of Protein Phosphorylation Regulation Of Transcription From RNA Polymerase III Promoter Regulation Of Lamellipodium Assembly Response To Stress Positive Regulation Of Acute Inflammatory Response Regulation Of Cellular Response To Heat Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Oxidation	Complement Activation, Alternative Pathway Regulation Of Complement Activation Regulation Of Humoral Immune Response Regulation Of Acute Inflammatory Response Complement Activation Protein Activation Cascade Positive Regulation Of Type IIa Hypersensitivity Humoral Immune Response Positive Regulation Of Activation Of Membrane Attack Complex DNA Recombinase Assembly Regulation Of Inflammatory Response Positive Regulation Of Hypersensitivity Positive Regulation Of Apoptotic Cell Clearance Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Protein Processing Regulation Of Apoptotic Cell Clearance Protein O-linked Fucosylation Regulation Of DNA Damage Checkpoint Positive Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Humoral Immune Response Nucleotide-excision Repair, DNA Gap Filling Nucleotide-excision Repair, DNA Damage Removal Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Protein Processing Regulation Of Triglyceride Biosynthetic Process Telomere Maintenance Via Semi-conservative Replication Astrocyte Development Nuclear DNA Replication Telomere Maintenance Via Recombination Positive Regulation Of Immune Response Positive Regulation Of Acute Inflammatory Response Regulation Of Double-strand Break Repair Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Regulation Of Cellular Response To Heat DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Fucosylation Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Lipid Storage Regulation Of Triglyceride Metabolic Process Positive Regulation Of Immunoglobulin Mediated Immune Response Regulation Of Cell Cycle Checkpoint Innate Immune Response Astrocyte Differentiation Transcription-coupled Nucleotide-excision Repair Regulation Of Immune Response Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Phagocytosis
Tagcloud ?		antigens cd4 confirming counts derivative donors fell filtrate h37rv hiv inducers kd mantoux mm3 mtbs mycobacterial portuguese ppd pulmonary retained secreted sonicate st stronger strongest supernatants switch tb th1	16s affiliated affiliation alphaproteobacteria antarctic antarctica argentinean assemblage assemblages bacteroides banks betaproteobacteria clones cyanobacteria cytophaga deposited divergent endemic flavobacteriia gammaproteobacteria jubany maritime phylogenetically remarkable richness seawater station summers undescribed
Tagcloud (Difference) ?		antigens cd4 confirming counts derivative donors fell filtrate h37rv hiv inducers kd mantoux mm3 mtbs mycobacterial portuguese ppd pulmonary retained secreted sonicate st stronger strongest supernatants switch tb th1	16s affiliated affiliation alphaproteobacteria antarctic antarctica argentinean assemblage assemblages bacteroides banks betaproteobacteria clones cyanobacteria cytophaga deposited divergent endemic flavobacteriia gammaproteobacteria jubany maritime phylogenetically remarkable richness seawater station summers undescribed
Tagcloud (Intersection) ?