PEX13 and PRRG4

Number of citations of the paper that reports this interaction (PubMedID 23873930)
23

Data Source:
BioGRID (pull down)

		PEX13	PRRG4
Description		peroxisomal biogenesis factor 13	proline rich and Gla domain 4
Image			No pdb structure
GO Annotations	Cellular Component	Peroxisome Peroxisomal Membrane Cytosol Membrane Peroxisomal Importomer Complex	Extracellular Region Extracellular Space Plasma Membrane Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Protein Binding Protein Transmembrane Transporter Activity	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding WW Domain Binding
	Biological Process	Fatty Acid Alpha-oxidation Neuron Migration Suckling Behavior Protein Monoubiquitination Locomotory Behavior Protein Transport Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Receptor Recycling Cerebral Cortex Cell Migration Cellular Response To Reactive Oxygen Species Protein Unfolding Protein Import Into Peroxisome Matrix, Substrate Release Microtubule-based Peroxisome Localization	Proteolysis Blood Coagulation
Pathways		E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import
Drugs
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Crohn's disease ( 22412388) Erectile dysfunction ( 30583798)	Parkinson's disease (age of onset) ( 19772629) Platelet count ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		6 interacting genes: CEP19 PEX19 PEX5 PEX7 PRRG4 SPRR2A	30 interacting genes: ABL2 AOC3 ARHGEF7 BCL10 ERBB3 ERBB4 FYN GRAP GRB2 HCK HDAC1 HECW1 HLA-C ITCH ITSN1 LYN MAGI2 MAGI3 NEBL NEDD4 OSTF1 PEX13 RBBP8 TEC UBE2K VAV2 VEGFA WWP1 WWTR1 YAP1
Entrez ID		5194	79056
HPRD ID		03475	15187
Ensembl ID		ENSG00000162928	ENSG00000135378
Uniprot IDs		Q92968	A0A0S2Z5M6 A0A0S2Z5N9 Q9BZD6
PDB IDs		7Z0I 7Z0J 7Z0K
Enriched GO Terms of Interacting Partners?		Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Peroxisome Organization Peroxisome Membrane Targeting Sequence Binding Peroxisomal Membrane Protein Import Into Peroxisome Membrane Protein Carrier Chaperone Peroxisome Protein Import Into Peroxisome Matrix Protein Targeting Intracellular Protein Transmembrane Transport Peroxisomal Matrix Fatty Acid Beta-oxidation Establishment Of Protein Localization To Organelle Fatty Acid Catabolic Process Protein Transmembrane Transport Fatty Acid Oxidation Peroxisome Matrix Targeting Signal-2 Binding Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Vesicle Targeting, Trans-Golgi To Periciliary Membrane Compartment Lipid Oxidation Intracellular Protein Transport Peroxisome Matrix Targeting Signal-1 Binding Lipid Modification Neuron Migration Protein Localization To Organelle Peroxisome Membrane Biogenesis Peroxisome Targeting Sequence Binding Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Vesicle Targeting, To, From Or Within Golgi Establishment Of Protein Localization To Membrane Protein Import Into Peroxisome Matrix, Substrate Release Carboxylic Acid Catabolic Process Membrane Biogenesis Host-mediated Modulation Of Intestinal Microbiota Composition Lipid Catabolic Process Protein Import Into Peroxisome Matrix, Receptor Recycling Peroxisome Fission Microtubule Anchoring At Centrosome Protein Transport Fatty Acid Metabolic Process Ether Lipid Biosynthetic Process Protein Unfolding Protein Localization To Membrane Microtubule Anchoring At Microtubule Organizing Center Organelle Organization Intracellular Transport	Signal Transduction Intracellular Signal Transduction Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Signal Transduction Positive Regulation Of Immune System Process Fc Receptor Mediated Stimulatory Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Immune Response Immune Response-activating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Modification Process Epidermal Growth Factor Receptor Binding Fc-gamma Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Activation Of Immune Response Regulation Of Cell Communication Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Cytoplasm Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Fc Receptor Signaling Pathway Regulation Of Immune Response Proline-rich Region Binding Epidermal Growth Factor Receptor Signaling Pathway Cytosol Antigen Receptor-mediated Signaling Pathway Regulation Of Cell Adhesion Plasma Membrane Neuregulin Receptor Activity Regulation Of Neuron Projection Development Regulation Of Immune System Process Protein Ubiquitination ERBB Signaling Pathway Regulation Of Cell Activation Adaptive Immune Response Positive Regulation Of Defense Response Receptor-mediated Endocytosis Negative Regulation Of Apoptotic Process
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