CYB5R2 and FFAR2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CYB5R2	FFAR2
Gene Name		cytochrome b5 reductase 2	free fatty acid receptor 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell Projection
	Molecular Function	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H	G-protein Coupled Receptor Activity Protein Binding Lipid Binding
	Biological Process	Sterol Biosynthetic Process Oxidation-reduction Process	Leukocyte Chemotaxis Involved In Inflammatory Response Mucosal Immune Response Regulation Of Acute Inflammatory Response Positive Regulation Of Cytokine Production Involved In Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus G-protein Coupled Receptor Signaling Pathway Lipid Storage Positive Regulation Of Chemokine Production Glucose Homeostasis Fat Cell Differentiation Cellular Response To Fatty Acid Regulation Of Peptide Hormone Secretion Positive Regulation Of Interleukin-8 Secretion
Pathways			G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Free fatty acid receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CDC23 COIL FFAR2 GOLGA2 PSMC6 TRAF1 TRAF2 TRIP13	4 interactors: CYB5R2 GNAO1 GNAQ IGF1R
Entrez ID		51700	2867
HPRD ID		06435	04824
Ensembl ID		ENSG00000166394	ENSG00000126262
Uniprot IDs		Q6BCY4	C6KYL4 O15552
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Positive Regulation Of Proteolysis Positive Regulation Of Cytokine Production Involved In Immune Response Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cell Cycle Negative Regulation Of Protein Ubiquitination Positive Regulation Of Transferase Activity Protein Ubiquitination Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Modification By Small Protein Conjugation Protein Catabolic Process Leukocyte Chemotaxis Involved In Inflammatory Response Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Regulation Of Proteolysis Activation Of Innate Immune Response Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Protein Binding Positive Regulation Of Cellular Protein Catabolic Process Cell Surface Pattern Recognition Receptor Signaling Pathway Mitotic Cell Cycle Checkpoint Mitotic Cell Cycle Positive Regulation Of Innate Immune Response Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Ubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Chromosome Segregation Regulation Of Cell Cycle Phase Transition Negative Regulation Of Glial Cell Apoptotic Process Cell Cycle Checkpoint Apoptotic Process Regulation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Dopamine Receptor Signaling Pathway Brain Development Head Development Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Inactivation Of MAPKK Activity G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuron Development Central Nervous System Development Neuron Differentiation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Negative Regulation Of Transferase Activity Negative Regulation Of Protein Phosphorylation Generation Of Neurons Positive Regulation Of Steroid Hormone Biosynthetic Process Exocrine Pancreas Development Neurogenesis Phospholipase C-activating Dopamine Receptor Signaling Pathway Neuron Remodeling Negative Regulation Of Phosphorylation Positive Regulation Of Hormone Biosynthetic Process Cell Development Forebrain Development Regulation Of Melanocyte Differentiation Male Sex Determination Maternal Behavior Response To Vitamin E Insulin-like Growth Factor Receptor Signaling Pathway Nervous System Development Behavior Regulation Of Catenin Import Into Nucleus Regulation Of Catalytic Activity Regulation Of Developmental Pigmentation Phosphatidylinositol 3-kinase Signaling Sex Determination Regulation Of Hormone Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Neuron Maturation Positive Regulation Of GTPase Activity Regulation Of Hormone Metabolic Process Regulation Of Protein Kinase Activity Negative Regulation Of Muscle Cell Apoptotic Process Forebrain Neuron Development Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Catalytic Activity Regulation Of GTPase Activity Positive Regulation Of Cytokinesis Regulation Of Kinase Activity Prostate Gland Epithelium Morphogenesis
Tagcloud ?		450k bnc1 clinicopathologic clustering comprehensively cpg cxxc5 cytosine densities dysregulation false fzd1 harbors hierarchical il1 illumina inactivation interrogating intraepithelial lmx1b methylated methylation myriad pca prostatic rpl39l syn2 top znf783	acetate alter autonomous believed coupling elevation encoded expect ffa2 ffa3 ffar3 gi glucose hyperglycemia inability indeed insufficient islets maintain obese pancreatic profound proper respond secretion stimulate summary tolerance worldwide
Tagcloud (Difference) ?		450k bnc1 clinicopathologic clustering comprehensively cpg cxxc5 cytosine densities dysregulation false fzd1 harbors hierarchical il1 illumina inactivation interrogating intraepithelial lmx1b methylated methylation myriad pca prostatic rpl39l syn2 top znf783	acetate alter autonomous believed coupling elevation encoded expect ffa2 ffa3 ffar3 gi glucose hyperglycemia inability indeed insufficient islets maintain obese pancreatic profound proper respond secretion stimulate summary tolerance worldwide
Tagcloud (Intersection) ?