VPS29 and TBC1D5

Number of citations of the paper that reports this interaction (PMID 22354992)
16

Data Source:
BioGRID (two hybrid, affinity chromatography technology, pull down)

		VPS29	TBC1D5
Gene Name		vacuolar protein sorting 29 homolog (S. cerevisiae)	TBC1 domain family, member 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Late Endosome Cytosol Endosome Membrane Retromer Complex Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Autophagic Vacuole Endosome Membrane AP-2 Adaptor Complex Retromer Complex ULK1-ATG13-FIP200 Complex
	Molecular Function	Protein Binding Zinc Ion Binding Protein Transporter Activity	Rab GTPase Activator Activity Protein Binding AP-2 Adaptor Complex Binding
	Biological Process	Intracellular Protein Transport Retrograde Transport, Endosome To Golgi Retrograde Transport, Endosome To Plasma Membrane	Positive Regulation Of Receptor Internalization Autophagy Positive Regulation Of Autophagy Protein Transport Positive Regulation Of Rab GTPase Activity Retrograde Transport, Endosome To Golgi Response To Starvation Regulation Of Cilium Assembly
Pathways		WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Signaling by Wnt Signaling by WNT in cancer WNT ligand biogenesis and trafficking
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: APP FRA10AC1 RGS2 TBC1D5 VPS35	7 interactors: AP2M1 ATXN1 EIF1AD GABARAPL1 GABARAPL2 MAP1LC3A VPS29
Entrez ID		51699	9779
HPRD ID		09499	10262
Ensembl ID		ENSG00000111237	ENSG00000131374
Uniprot IDs		F8VXU5 Q9UBQ0	B9A6K1 Q92609
PDB IDs		1W24 2R17
Enriched GO Terms of Interacting Partners?		Retrograde Transport, Endosome To Golgi Synaptic Growth At Neuromuscular Junction Negative Regulation Of Late Endosome To Lysosome Transport Positive Regulation Of Hydrolase Activity Endosomal Transport Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Translation Vesicle-mediated Transport Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Adrenergic Receptor Signaling Pathway Intracellular Transport Positive Regulation Of Catalytic Activity Axon Choice Point Recognition Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Phospholipase Activity Neuron Remodeling Relaxation Of Vascular Smooth Muscle Retrograde Transport, Endosome To Plasma Membrane Relaxation Of Smooth Muscle Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Hydrolase Activity Positive Regulation Of Striated Muscle Contraction Negative Regulation Of Muscle Hypertrophy Transcytosis Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Microtubule Polymerization Relaxation Of Cardiac Muscle Establishment Of Localization In Cell Negative Regulation Of Smooth Muscle Contraction Cellular Copper Ion Homeostasis Positive Regulation Of Receptor Internalization Negative Regulation Of Lipase Activity Negative Regulation Of Muscle Contraction Regulation Of CAMP-mediated Signaling Relaxation Of Muscle Copper Ion Homeostasis Suckling Behavior Regulation Of Catalytic Activity Cellular Localization Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Heart Contraction Regulation Of Microtubule Polymerization Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Cardiac Muscle Hypertrophy Regulation Of Receptor Internalization	Nucleophagy Mitochondrion Degradation Organelle Disassembly Autophagic Vacuole Assembly Macroautophagy Vacuole Organization Membrane Fusion Cellular Response To Starvation Cellular Response To Nitrogen Starvation Autophagy Cellular Response To Nutrient Levels Response To Starvation Cellular Response To Extracellular Stimulus Membrane Organization Mitochondrion Organization Response To Nutrient Levels Response To Extracellular Stimulus Organelle Assembly Intracellular Transport Response To External Stimulus Establishment Of Localization In Cell Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Localization Retrograde Transport, Endosome To Plasma Membrane Protein Transport Negative Regulation Of Protein Localization To Plasma Membrane Vesicle-mediated Transport Establishment Of Protein Localization Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Cellular Response To Stress
Tagcloud ?		branched building cargo comprises coordinate dimer dysregulation endosomal endosome fam21 laboratories nexins operate recruits retromer rme snx1 sort sorting subcomplexes trimer tubulate tubulating tubulation tubules vital vps26 vps35 wash	2z1 away barrel buds cerebellar cortex delineates fastigial flanking gabaergic inserted insertion insertional interneurons lacz landscape mapped mutagenesis neighbors nuclei pontine remote resembles satb1 somatosensory subdomain thymic tooth transgene
Tagcloud (Difference) ?		branched building cargo comprises coordinate dimer dysregulation endosomal endosome fam21 laboratories nexins operate recruits retromer rme snx1 sort sorting subcomplexes trimer tubulate tubulating tubulation tubules vital vps26 vps35 wash	2z1 away barrel buds cerebellar cortex delineates fastigial flanking gabaergic inserted insertion insertional interneurons lacz landscape mapped mutagenesis neighbors nuclei pontine remote resembles satb1 somatosensory subdomain thymic tooth transgene
Tagcloud (Intersection) ?