PRP4K and HSPB3

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PRP4K	HSPB3
Description		pre-mRNA processing factor kinase PRP4K	heat shock protein family B (small) member 3
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Spliceosomal Complex Chromosome Nuclear Speck Catalytic Step 2 Spliceosome	Nucleus Cytoplasm Nuclear Speck
	Molecular Function	Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Hippo Signaling Positive Regulation Of Hippo Signaling MRNA Cis Splicing, Via Spliceosome Positive Regulation Of Protein Export From Nucleus Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint	Response To Unfolded Protein
Pathways		mRNA Splicing - Major Pathway
Drugs		Fostamatinib
Diseases
GWAS			Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Systolic blood pressure (dietary potassium intake interaction) ( 29212900)
Interacting Genes		9 interacting genes: CLK1 HSPB3 KLF13 PNN POLR3F RNF10 SRPK2 SRSF1 YWHAG	19 interacting genes: ANP32A BBOX1 HSPB2 HSPB8 LRIF1 LSM14B MED31 MED8 MRPL38 NSMF OLFML3 PRP4K RAMP3 RBM48 RTL8A SETDB1 TCAP UNC119 ZZEF1
Entrez ID		8899	8988
HPRD ID		09087	06861
Ensembl ID		ENSG00000112739	ENSG00000169271
Uniprot IDs		Q13523	Q12988 Q6ICS9
PDB IDs		4IAN 4IFC 4IIR 4IJP 6CNH 6PJJ 6PK6 6QX9 8H6E 8H6J 8QXD 8R08 8R0A 8Y6O	6F2R
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Splicing Nuclear Speck Exon-exon Junction Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Peptidyl-serine Phosphorylation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Protein Serine Kinase Activity Nucleus Macromolecule Metabolic Process RNA Metabolic Process RNA Splicing Catalytic Step 2 Spliceosome Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Protein Localization To P-body Positive Regulation Of Neuron Apoptotic Process Ripoptosome Assembly Ripoptosome Assembly Involved In Necroptotic Process Protein Serine/threonine Kinase Activity MRNA Processing Protein Kinase C Inhibitor Activity Positive Regulation Of Interleukin-6-mediated Signaling Pathway Death Domain Binding Regulation Of MRNA Splicing, Via Spliceosome DNA Topoisomerase Binding Nuclear Speck Organization Regulation Of Macromolecule Metabolic Process Protein Kinase Activity Regulation Of MRNA Processing Positive Regulation Of MiRNA Processing Peptidyl-serine Autophosphorylation Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane
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