METTL13 and EDEM3

		METTL13	EDEM3
Description		methyltransferase 13, eEF1A N-terminus and K55	ER degradation enhancing alpha-mannosidase like protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Catalytic Activity Protein Binding Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity	Mannosyl-oligosaccharide 1,2-alpha-mannosidase Activity Calcium Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Methylation	Carbohydrate Metabolic Process Protein Glycosylation Response To Unfolded Protein Endoplasmic Reticulum Unfolded Protein Response ERAD Pathway Ubiquitin-dependent Glycoprotein ERAD Pathway Endoplasmic Reticulum Mannose Trimming
Pathways			ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Diffusing capacity of carbon monoxide ( 30694715) Platelet distribution width ( 32888494)	Adult body size ( 32376654) Body size at age 10 ( 32376654) Cerebrospinal fluid immune biomarker levels ( 32066700) Estimated glomerular filtration rate ( 31152163) Liver enzyme levels (alkaline phosphatase) ( 33972514) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Systemic lupus erythematosus ( 24871463) Urinary albumin-to-creatinine ratio ( 31511532 31630189) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		5 interacting genes: SNRPA THAP1 TRAF2 UBC VPS52	2 interacting genes: TRA TXNDC5
Entrez ID		51603	80267
HPRD ID		13821	10724
Ensembl ID		ENSG00000010165	ENSG00000116406
Uniprot IDs		C4B4C6 Q8N6R0	A0A8J8YX80 Q9BZQ6
PDB IDs		5WCJ
Enriched GO Terms of Interacting Partners?		Embryonic Ectodermal Digestive Tract Development TORC2 Complex Disassembly TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Ubiquitin-dependent Glycoprotein ERAD Pathway GARP Complex EARP Complex Ectodermal Cell Differentiation Spliceosomal SnRNP Complex Sphingolipid Binding IRE1-TRAF2-ASK1 Complex CD27 Signaling Pathway Tumor Necrosis Factor Receptor Superfamily Complex	Detection Of Tumor Cell T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Alpha-beta T Cell Receptor Complex Immune Response To Tumor Cell T Cell Mediated Cytotoxicity T Cell Receptor Complex Beta-catenin Destruction Complex Nuclear Envelope Lumen S100 Protein Binding Response To Growth Hormone Intracellular Organelle Lumen Protein Disulfide Isomerase Activity Protein-disulfide Reductase Activity Protein-lysine N-methyltransferase Activity
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