ARMCX3 and EHHADH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARMCX3	EHHADH
Description		armadillo repeat containing X-linked 3	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Axon Cytoplasm	Peroxisome Peroxisomal Matrix Cytosol
	Molecular Function	Protein Binding	Catalytic Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Delta(3)-delta(2)-enoyl-CoA Isomerase Activity Enoyl-CoA Hydratase Activity Protein Binding Oxidoreductase Activity Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Lyase Activity Isomerase Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds 3-hydroxyacyl-CoA Dehydratase Activity Enzyme Binding NAD+ Binding
	Biological Process	Mitochondrion Organization Intracellular Protein Localization Axonal Transport Of Mitochondrion Positive Regulation Of Transcription By RNA Polymerase II	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Unsaturated Fatty Acid Biosynthetic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Fatty Acid Derivative Biosynthetic Process
Pathways		RAC2 GTPase cycle	Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import
Drugs			NADH
Diseases
GWAS			Cognitive performance ( 19734545) Major depressive disorder ( 21042317 27519822)
Interacting Genes		9 interacting genes: APP CLTC CSNK2A1 EHHADH FAM25A FAM25C FAM25G IMMT PTEN	98 interacting genes: AARS2 ACTB ACTG1 ADARB1 ANKRD36B ARMC12 ARMCX3 BHLHE40 BOLL CAT CBS CCDC102B CCDC13 CDR2L CEP83 CISD2 CLDN18 CLDN5 CLK2 CMTM6 COQ9 CYB561 CYB561A3 DAAM2 DERL3 DES DRC4 EMP1 ERGIC1 FGF14 FUNDC1 GMCL1 GRIPAP1 HID1 HIP1 HSD17B11 HTATIP2 JAGN1 KCTD9 KRTAP10-7 KRTAP4-11 LCN2 LEPROTL1 LYPD5 LZTFL1 LZTS2 MAB21L3 MID1 MTUS2 NACC1 NECAB2 OPRM1 ORMDL1 PAQR8 PICK1 PNMA1 PNMA5 PPP1R12C PRKRA PSTPIP1 PTGES REL RNF4 RPRM RUSF1 SCARA5 SCP2 SDR16C5 SGCB SLC14A2 SLC39A2 SMIM5 SMN1 SMN2 SSNA1 SSX2IP SYNGR3 TMEM121 TMEM17 TMEM31 TMEM35A TNIP1 TPP2 TRAF1 TRIM21 TRIM23 TRIM27 TRIM41 TRIM5 TRIM54 TRIM55 TRIM63 VAC14 ZBTB10 ZBTB26 ZBTB8A ZBTB9 ZCCHC17
Entrez ID		51566	1962
HPRD ID		02294	06125
Ensembl ID		ENSG00000102401	ENSG00000113790
Uniprot IDs		Q9UH62	Q08426
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Excitatory Postsynaptic Potential Low-density Lipoprotein Particle Receptor Binding Reproductive Behavior Ubiquitin-specific Protease Binding Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Neuron Projection Organization Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Central Nervous System Development Intermediate-density Lipoprotein Particle Enzyme Binding Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Trans-Golgi Network Membrane Amylin Binding Regulation Of Proteolysis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Adult Behavior Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Clathrin-coated Pit Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Regulation Of Nervous System Process Modulation Of Excitatory Postsynaptic Potential Microglia Development Dendritic Spine Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Regulation Of Cell Cycle Osteoblast Differentiation Negative Regulation Of Hyaluronan Biosynthetic Process Clathrin Coat Disassembly Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Aggrephagy PML Body	Identical Protein Binding Protein Binding Ubiquitin Protein Ligase Activity Negative Regulation Of Protein Localization Innate Immune Response Protein K63-linked Ubiquitination Suppression Of Viral Release By Host Regulation Of Transepithelial Transport
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