RAB14 and FGA

		RAB14	FGA
Description		RAB14, member RAS oncogene family	fibrinogen alpha chain
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GO Annotations	Cellular Component	Golgi Membrane Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Rough Endoplasmic Reticulum Golgi Apparatus Golgi Stack Trans-Golgi Network Cytosol Plasma Membrane Cilium Endomembrane System Membrane Trans-Golgi Network Transport Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Nuclear Outer Membrane-endoplasmic Reticulum Membrane Network Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Membrane	Extracellular Region Fibrinogen Complex Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Plasma Membrane External Side Of Plasma Membrane Cell Surface Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle Extracellular Vesicle
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Myosin V Binding	Signaling Receptor Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Phagolysosome Assembly Intracellular Protein Transport Golgi To Endosome Transport Fibroblast Growth Factor Receptor Signaling Pathway Protein Transport Vesicle-mediated Transport Endocytic Recycling Regulation Of Protein Localization Endosomal Vesicle Fusion Early Endosome To Golgi Transport Defense Response To Bacterium Regulation Of Embryonic Development Intracellular Transport Phagosome Maturation	Adaptive Immune Response Immune System Process Cell-matrix Adhesion Blood Coagulation Hemostasis Platelet Activation Plasminogen Activation Positive Regulation Of Heterotypic Cell-cell Adhesion Fibrinolysis Induction Of Bacterial Agglutination Innate Immune Response Positive Regulation Of Vasoconstriction Positive Regulation Of Exocytosis Positive Regulation Of Protein Secretion Protein Polymerization Response To Calcium Ion Protein-containing Complex Assembly Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Blood Coagulation, Common Pathway Blood Coagulation, Fibrin Clot Formation Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Blood Coagulation, Common Pathway Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Synthesis of PIPs at the plasma membrane Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Platelet degranulation ER-Phagosome pathway Common Pathway of Fibrin Clot Formation MyD88:MAL(TIRAP) cascade initiated on plasma membrane Integrin cell surface interactions Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) MAP2K and MAPK activation Regulation of TLR by endogenous ligand Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Post-translational protein phosphorylation Signaling downstream of RAS mutants Signaling by RAF1 mutants Amyloid fiber formation
Drugs			Alteplase Reteplase Anistreplase Tenecteplase Sucralfate Zinc Alfimeprase Ancrod EP-2104R Lanoteplase Thrombin Prothrombin Human thrombin Thrombin alfa Anti-inhibitor coagulant complex Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Familial amyloidosis Inherited thrombophilia Afibrinogenemia; Dysfibrinogenemia
GWAS		Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)	D-dimer levels ( 21502573) Fibrinogen ( 20031577 21757653) Venous thromboembolism ( 21980494 30659681 33592630)
Interacting Genes		13 interacting genes: ADRB2 APP ARL8B CHM EXOC5 GARIN6 OCRL OPTN RAB11FIP5 RBSN RUFY1 SH3BP5L SMURF2	30 interacting genes: AGTRAP APP CDH5 EXOC5 F13A1 F2 FGB FGG HRG HSP90AA1 ITGA2B ITGB3 LRP1B MEOX2 NID1 PLAT PRRC2A SERPINA5 SERPINF2 SH3BP1 STX1B STX2 SYCE1L TFIP11 THBS1 TMEM43 TPM1 TPM3 UBC VWF
Entrez ID		51552	2243
HPRD ID		06693	00619
Ensembl ID		ENSG00000119396	ENSG00000171560
Uniprot IDs		P61106	P02671
PDB IDs		1Z0F 4D0G 4DRZ	1BBR 1DM4 1FPH 1FZA 1FZB 1FZC 1FZD 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 1YCP 2A45 2FFD 2H43 2HLO 2HOD 2HPC 2OYH 2OYI 2Q9I 2XNX 2XNY 2Z4E 3AT0 3BVH 3E1I 3GHG 3H32 3HUS 4F27 5CFA
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endosome Early Endosome Membrane Early Endosome To Golgi Transport Early Endosome Small GTPase Binding Golgi Vesicle Transport Cellular Response To Amyloid-beta Response To Amyloid-beta Innate Immune Response Response To Mechanical Stimulus Positive Regulation Of CAMP/PKA Signal Transduction Golgi-associated Vesicle Defense Response To Symbiont Defense Response To Gram-negative Bacterium Protein Transport Endosomal Vesicle Fusion Cellular Localization Defense Response To Other Organism Retrograde Transport, Endosome To Golgi Platelet Alpha Granule Post-Golgi Vesicle-mediated Transport Neuronal Dense Core Vesicle Defense Response To Bacterium Lysosomal Transport Establishment Of Protein Localization Cytosolic Transport Recycling Endosome Amyloid Fibril Formation Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Ligand-gated Ion Channel Signaling Pathway Vacuolar Transport Negative Regulation Of Cell Communication Positive Regulation Of Mini Excitatory Postsynaptic Potential Negative Regulation Of Signaling Amyloid-beta Complex Regulation Of Extrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Response To Bacterium Positive Regulation Of Nitric Oxide Metabolic Process Negative Regulation Of Blood Coagulation, Common Pathway Membrane Organization Regulation Of Plasma Membrane Raft Polarization Phosphatidylinositol 3-kinase Catalytic Subunit Binding	Platelet Alpha Granule Lumen Platelet Alpha Granule Fibrinolysis Blood Coagulation, Fibrin Clot Formation Extracellular Matrix Negative Regulation Of Fibrinolysis Coagulation Blood Coagulation Hemostasis Regulation Of Blood Coagulation Regulation Of Body Fluid Levels Regulation Of Hemostasis Regulation Of Fibrinolysis Protein Activation Cascade Negative Regulation Of Blood Coagulation Fibrinogen Binding Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Fibrinogen Complex Positive Regulation Of Blood Coagulation Extracellular Exosome Blood Microparticle Positive Regulation Of Coagulation Platelet Activation Negative Regulation Of Wound Healing Regulation Of Wound Healing External Side Of Plasma Membrane Cell Surface Regulation Of Response To Wounding Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Wound Healing Negative Regulation Of Plasminogen Activation Extracellular Matrix Binding Cell-substrate Adhesion Regulation Of Biological Quality Signaling Receptor Binding Negative Regulation Of Endothelial Cell Apoptotic Process Plasminogen Activation Cell-matrix Adhesion Protease Binding Extracellular Matrix Structural Constituent Regulation Of Cell-substrate Adhesion Positive Regulation Of Cell-substrate Adhesion Regulation Of Plasminogen Activation Extracellular Space Negative Regulation Of Protein Processing Heparin Binding Integrin AlphaIIb-beta3 Complex Negative Regulation Of Protein Maturation Membrane Organization
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