ETFDH

Description		electron transfer flavoprotein dehydrogenase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol Membrane Mitochondrial Membrane
	Molecular Function	Electron-transferring-flavoprotein Dehydrogenase Activity Protein Binding Electron Transfer Activity Oxidoreductase Activity Metal Ion Binding Quinone Binding Ubiquinone Binding Flavin Adenine Dinucleotide Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Response To Oxidative Stress Electron Transport Chain Respiratory Electron Transport Chain Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase
Pathways		Respiratory electron transport
Drugs		Metformin 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol
Diseases		Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency
GWAS		Metabolic traits ( 21886157) Metabolite levels ( 20037589 31628463) Serum metabolite levels ( 23093944 33031748)
Novel Interacting Genes		1 novel interacting genes: CLCN3
Interacting Genes		8 interacting genes: GSC2 HSD17B10 KRTAP11-1 KRTAP13-2 MYH7B OTX1 TRIM69 ZNF581
Entrez ID		2110
HPRD ID		01978
Ensembl ID		ENSG00000171503
Uniprot IDs		B4DEQ0 Q16134
PDB IDs
Enriched GO Terms of Interacting Partners?		Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Diencephalon Morphogenesis Chloride:proton Antiporter Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Brexanolone Metabolic Process Mitochondrial Ribonuclease P Complex Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing Mitochondrial TRNA Methylation Metencephalon Development Keratin Filament Negative Regulation Of Cell Volume Volume-sensitive Chloride Channel Activity TRNA Methyltransferase Complex Mitochondrial RNA 3'-end Processing Testosterone Dehydrogenase (NAD+) Activity Isoleucine Metabolic Process L-isoleucine Catabolic Process Mitochondrial RNA 5'-end Processing (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Regulation Of CAMKK-AMPK Signaling Cascade Intermediate Filament Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity Cardiac Myofibril Structural Molecule Activity DNA-binding Transcription Factor Activity TRNA 3'-end Processing
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