ETFDH and KRTAP13-2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ETFDH	KRTAP13-2
Description		electron transfer flavoprotein dehydrogenase	keratin associated protein 13-2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol Membrane Mitochondrial Membrane	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Electron-transferring-flavoprotein Dehydrogenase Activity Protein Binding Electron Transfer Activity Oxidoreductase Activity Metal Ion Binding Quinone Binding Ubiquinone Binding Flavin Adenine Dinucleotide Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	Structural Molecule Activity Protein Binding
	Biological Process	Response To Oxidative Stress Electron Transport Chain Respiratory Electron Transport Chain Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase
Pathways		Respiratory electron transport	Keratinization
Drugs		Metformin 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol
Diseases		Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency
GWAS		Metabolic traits ( 21886157) Metabolite levels ( 20037589 31628463) Serum metabolite levels ( 23093944 33031748)
Interacting Genes		8 interacting genes: GSC2 HSD17B10 KRTAP11-1 KRTAP13-2 MYH7B OTX1 TRIM69 ZNF581	81 interacting genes: ANAPC11 ANXA11 BCL6 C22orf39 CBFA2T2 CCDC125 CCDC24 CCDC57 CCNK CFAP68 CRYBA1 CSKMT CYSRT1 ENKD1 EPDR1 ETFDH FANCL FBXO17 FCHO1 GATA3 GEMIN4 GNE GPS2 GRN HNRNPH1 HOXA1 HR KCTD9 KLHL38 KPRP KRT3 KRTAP1-1 KRTAP10-5 KRTAP10-8 KRTAP11-1 KRTAP12-2 KRTAP12-3 KRTAP15-1 KRTAP26-1 KRTAP3-1 KRTAP3-3 KRTAP4-4 KRTAP4-5 KRTAP9-2 MAGOHB MEOX2 MGAT5B NBPF19 NEK8 NHLRC4 NOTCH2NLA OIP5 OTX1 P4HB PATZ1 PHETA1 PITX1 POU2AF1 RECK RHOXF2 SAXO4 SLC25A18 SLIT1 SMUG1 SNRPC SPEF1 SPMIP9 SSC4D STK16 TCAF1 TLE5 TNS2 TRAPPC6A TRIM68 TSPYL6 TSSK3 UNC5CL VGLL3 VWC2 YPEL3 ZIC1
Entrez ID		2110	337959
HPRD ID		01978	11201
Ensembl ID		ENSG00000171503	ENSG00000182816
Uniprot IDs		B4DEQ0 Q16134	Q52LG2
PDB IDs
Enriched GO Terms of Interacting Partners?		Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Diencephalon Morphogenesis Chloride:proton Antiporter Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Brexanolone Metabolic Process Mitochondrial Ribonuclease P Complex Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing Mitochondrial TRNA Methylation Metencephalon Development Keratin Filament Negative Regulation Of Cell Volume Volume-sensitive Chloride Channel Activity TRNA Methyltransferase Complex Mitochondrial RNA 3'-end Processing Testosterone Dehydrogenase (NAD+) Activity Isoleucine Metabolic Process L-isoleucine Catabolic Process Mitochondrial RNA 5'-end Processing (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Regulation Of CAMKK-AMPK Signaling Cascade Intermediate Filament Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity Cardiac Myofibril Structural Molecule Activity DNA-binding Transcription Factor Activity TRNA 3'-end Processing	Intermediate Filament Keratin Filament Protein Binding
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