VPS54 and VPS51

Number of citations of the paper that reports this interaction (PubMedID 27440922)
60

Data Source:
BioGRID (affinity chromatography technology, pull down, biochemical)

		VPS54	VPS51
Description		VPS54 subunit of GARP complex	VPS51 subunit of GARP complex
Image		No pdb structure
GO Annotations	Cellular Component	GARP Complex Nucleoplasm Cytoplasm Mitochondrion Golgi Apparatus Trans-Golgi Network Cytosol Membrane Trans-Golgi Network Membrane Synapse Perinuclear Region Of Cytoplasm	GARP Complex Nucleolus Endosome Golgi Apparatus Trans-Golgi Network Cytosol Membrane Trans-Golgi Network Membrane Recycling Endosome EARP Complex
	Molecular Function	Protein Binding Syntaxin Binding	Protein Binding
	Biological Process	In Utero Embryonic Development Apoptotic DNA Fragmentation Protein Targeting To Lysosome Protein Targeting To Vacuole Intracellular Calcium Ion Homeostasis Golgi To Vacuole Transport Striated Muscle Contraction Mitochondrion Organization Vacuole Organization Lysosomal Transport Neuromuscular Synaptic Transmission Skeletal Muscle Tissue Development Intracellular Protein Localization Gene Expression Ubiquitin Recycling Microglia Differentiation Protein Transport Respiratory Electron Transport Chain Sphingolipid Catabolic Process Protein Localization To Cell Surface Limb Morphogenesis Post-embryonic Forelimb Morphogenesis Synaptic Transmission, Glutamatergic Regulation Of Growth Retrograde Transport, Endosome To Golgi Protein Targeting To ER Response To Antibiotic Spermatid Differentiation Skeletal Muscle Tissue Growth Astrocyte Differentiation Neuron Projection Morphogenesis Homeostasis Of Number Of Cells Homeostasis Of Number Of Cells Within A Tissue Musculoskeletal Movement Neuron Apoptotic Process Response To Calcium Ion Synaptic Transmission, GABAergic L-glutamate Import Neurofilament Cytoskeleton Organization Limb Development Motor Behavior Thrombin-activated Receptor Signaling Pathway Cellular Response To Progesterone Stimulus Vesicle-mediated Cholesterol Transport Motor Neuron Apoptotic Process Neural Tissue Regeneration Neuroinflammatory Response Negative Regulation Of Motor Neuron Apoptotic Process	Protein Targeting Lipid Transport Autophagy Golgi Organization Lysosomal Transport Protein Transport Endocytic Recycling Retrograde Transport, Endosome To Golgi Golgi Vesicle Transport Brain Morphogenesis Vesicle-mediated Cholesterol Transport
Pathways		Retrograde transport at the Trans-Golgi-Network	Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Clozapine-induced agranulocytosis ( 25187353) Diastolic blood pressure ( 30224653)	Serum uric acid levels ( 32514006)
Interacting Genes		5 interacting genes: DSCAM DSCR9 DYRK1A KLHL20 VPS51	6 interacting genes: CDKN1A FXR1 GSK3B NUDT3 VPS54 YTHDC1
Entrez ID		51542	738
HPRD ID		10302	12605
Ensembl ID		ENSG00000143952	ENSG00000149823
Uniprot IDs		Q9P1Q0	Q9UID3
PDB IDs			4J2C
Enriched GO Terms of Interacting Partners?		Axon Dendrite Histone H3T45 Kinase Activity Glucosidase Activity Glc3Man9GlcNAc2 Oligosaccharide Glucosidase Activity Type II Interferon Binding Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Protein K33-linked Ubiquitination Cytosolic Transport GARP Complex Trans-Golgi Network EARP Complex Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding	Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Chordate Embryonic Development In Utero Embryonic Development Presynaptic Modulation Of Chemical Synaptic Transmission Cytoplasmic Translational Initiation Regulation Of Long-term Synaptic Potentiation Tissue Regeneration PCNA-p21 Complex Cell Cycle G1/S Phase Transition Cellular Localization Negative Regulation Of Cardiac Muscle Tissue Regeneration Regulation Of Growth G1/S Transition Of Mitotic Cell Cycle Regeneration Negative Regulation Of Gene Expression Negative Regulation Of Protein Metabolic Process Regulation Of Circadian Rhythm Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Microtubule Anchoring At Centrosome Glutamatergic Synapse Translational Initiation Regulation Of Translation At Presynapse, Modulating Synaptic Transmission MRNA Transport 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] Diphosphatase Activity Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Diphosphoinositol Polyphosphate Metabolic Process Inositol Diphosphate Pentakisphosphate Diphosphatase Activity Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity Diphosphoinositol Polyphosphate Catabolic Process Bis(5'-adenosyl)-hexaphosphatase Activity Diadenosine Hexaphosphate Catabolic Process Inositol Phosphate Catabolic Process Diadenosine Pentaphosphate Catabolic Process Adenosine 5'-(hexahydrogen Pentaphosphate) Catabolic Process Diphosphoinositol-polyphosphate Diphosphatase Activity Endopolyphosphatase Activity Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity Neural Tissue Regeneration Post-embryonic Forelimb Morphogenesis Primary Follicle Stage Mammalian Oogenesis Stage Mitotic Cell Cycle Phase Transition RNA Transport Negative Regulation Of Catalytic Activity Cell Cycle Phase Transition
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