JKAMP and RNF5

Number of citations of the paper that reports this interaction (PMID 19269966)
10

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		JKAMP	RNF5
Gene Name		JNK1/MAPK8-associated membrane protein	ring finger protein 5, E3 ubiquitin protein ligase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function	Ubiquitin Protein Ligase Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Response To Unfolded Protein ER-associated Ubiquitin-dependent Protein Catabolic Process	Response To Bacterium Negative Regulation Of Autophagy Protein Destabilization Cellular Protein Catabolic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination ER-associated Misfolded Protein Catabolic Process Regulation Of Autophagic Vacuole Assembly
Pathways
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		2 interactors: MAPK8 RNF5	32 interactors: ABHD16A CFTR CYB561 CYB561A3 FHOD1 INSIG2 JKAMP MAVS MPDZ PXN RNF185 SEC22A SLC1A1 SLC38A7 TGFBR1 TMEM242 TNFAIP3 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2K UBE2N UBE2U UBE2V1 UBE2W UBE2Z YIPF2
Entrez ID		51528	6048
HPRD ID		12623	04057
Ensembl ID			ENSG00000204308
Uniprot IDs		Q9P055	Q99942
PDB IDs
Enriched GO Terms of Interacting Partners?		ER-associated Misfolded Protein Catabolic Process JUN Phosphorylation Response To Bacterium Positive Regulation Of Deacetylase Activity Positive Regulation Of Determination Of Dorsal Identity Response To Other Organism Response To Biotic Stimulus Cellular Response To Nitric Oxide Misfolded Or Incompletely Synthesized Protein Catabolic Process Cellular Response To Misfolded Protein Response To Nitric Oxide Regulation Of Autophagic Vacuole Assembly Response To Misfolded Protein Regulation Of Vacuole Organization Regulation Of Organelle Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cellular Response To Reactive Nitrogen Species Protein Destabilization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Protein K63-linked Ubiquitination Negative Regulation Of Autophagy Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Histone Deacetylation Protein K48-linked Ubiquitination ER-associated Ubiquitin-dependent Protein Catabolic Process Programmed Necrotic Cell Death Peptidyl-threonine Phosphorylation Necrotic Cell Death Cellular Response To Stress Regulation Of Protein Deacetylation Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Protein Binding Response To Cadmium Ion Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Mitochondrion Organization Cellular Response To Hydrogen Peroxide Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Response To External Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Organic Substance Toll-like Receptor 4 Signaling Pathway Regulation Of Cellular Component Organization JNK Cascade	Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Activation Of Innate Immune Response Protein K63-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Positive Regulation Of Innate Immune Response Cellular Protein Modification Process Regulation Of Innate Immune Response Cellular Macromolecule Catabolic Process Toll-like Receptor 4 Signaling Pathway Cellular Protein Metabolic Process Cellular Response To Stress Toll-like Receptor Signaling Pathway Proteolysis Immune Response-regulating Signaling Pathway Protein Metabolic Process Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Protein Ubiquitination Catabolic Process Positive Regulation Of Immune Response Histone Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Monoubiquitination Response To Organic Substance Negative Regulation Of Type I Interferon Production ISG15-protein Conjugation Aspartate Transport Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Innate Immune Response Regulation Of DNA-templated Transcription In Response To Stress Cellular Response To Organic Substance TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Immune Response Cellular Response To Transforming Growth Factor Beta Stimulus MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway
Tagcloud ?			adapt autoadaptive built cleared clients deploys dislocation dislocon dislocons engage erad folding herp hrd1 interrupt ligases machineries misfolded p97 perturbation polyubiquitylation preempt proteasomal proteostasis relay relies tuning turnover ubc6e
Tagcloud (Difference) ?			adapt autoadaptive built cleared clients deploys dislocation dislocon dislocons engage erad folding herp hrd1 interrupt ligases machineries misfolded p97 perturbation polyubiquitylation preempt proteasomal proteostasis relay relies tuning turnover ubc6e
Tagcloud (Intersection) ?