UFC1 and UFM1

Number of citations of the paper that reports this interaction (PMID 22939629)
44

Data Source:
BioGRID (affinity chromatography technology, biochemical, pull down)

		UFC1	UFM1
Gene Name		ubiquitin-fold modifier conjugating enzyme 1	ubiquitin-fold modifier 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Vesicular Exosome	Nucleus Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Binding UFM1 Transferase Activity
	Biological Process	Response To Endoplasmic Reticulum Stress Protein Ufmylation Protein Polyufmylation	Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Endoplasmic Reticulum Stress Protein Ufmylation Protein Polyufmylation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: UFM1	14 interactors: ARHGDIA ARHGDIB DIABLO GSK3B RPS6KA6 UBA5 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2W UFC1
Entrez ID		51506	51569
HPRD ID		15643	15644
Ensembl ID		ENSG00000143222	ENSG00000120686
Uniprot IDs		Q9Y3C8	P61960
PDB IDs		2K07 2Z6O 2Z6P 3EVX	1WXS
Enriched GO Terms of Interacting Partners?		Protein Polyufmylation Protein Ufmylation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Response To Endoplasmic Reticulum Stress	Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Protein Ubiquitination Cellular Response To Stress Cellular Protein Modification Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein Metabolic Process Cellular Protein Metabolic Process Protein Monoubiquitination Protein Polyufmylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Ufmylation Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Response To Stimulus Proteolysis Involved In Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Catabolic Process Proteasomal Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Protein Catabolic Process Positive Regulation Of Proteolysis Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Response To Stress Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Activation Of Innate Immune Response Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Response To Endoplasmic Reticulum Stress Response To Stimulus Immune Response-regulating Signaling Pathway Positive Regulation Of Catalytic Activity Positive Regulation Of Innate Immune Response Protein K63-linked Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint
Tagcloud ?		adduct adenylate ads binary catalysis conjugating conjugation contrasts covalent detail e1 hct116 initiate interrogating modifier ordered pan ppi pyrophosphate reacted sulfamate ternary thioester tight transthiolation uba1 uba5 ubl ufm1	17beta abrogated activating asc1 bound coactivator displaced e1 e2 eralpha establish estradiol knockdown largely maintains nonufmylated polyufmylation prevented promoted promoters promoting protease screened src1 tamoxifen transactivation uba5 ufmylation ufsp2
Tagcloud (Difference) ?		adduct adenylate ads binary catalysis conjugating conjugation contrasts covalent detail hct116 initiate interrogating modifier ordered pan ppi pyrophosphate reacted sulfamate ternary thioester tight transthiolation uba1 ubl	17beta abrogated activating asc1 bound coactivator displaced e2 eralpha establish estradiol knockdown largely maintains nonufmylated polyufmylation prevented promoted promoters promoting protease screened src1 tamoxifen transactivation ufmylation ufsp2
Tagcloud (Intersection) ?		e1 uba5 ufm1