PDE6G and SLC27A2

		PDE6G	SLC27A2
Description		phosphodiesterase 6G	solute carrier family 27 member 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Photoreceptor Outer Segment Membrane Photoreceptor Disc Membrane	Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Specific Granule Membrane Extracellular Exosome
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity Enzyme Inhibitor Activity Protein Binding Hydrolase Activity Spectrin Binding CGMP Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Nucleotide Binding Long-chain Fatty Acid-CoA Ligase Activity Long-chain Fatty Acid Transmembrane Transporter Activity ATP Binding Fatty Acid Transmembrane Transporter Activity Ligase Activity Enzyme Binding Very Long-chain Fatty Acid-CoA Ligase Activity Arachidonate-CoA Ligase Activity Cholate-CoA Ligase Activity Phytanate-CoA Ligase Activity Pristanate-CoA Ligase Activity
	Biological Process	Visual Perception Positive Regulation Of MAPK Cascade Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway	Very Long-chain Fatty Acid Metabolic Process Fatty Acid Alpha-oxidation Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Bile Acid Biosynthetic Process Lipid Transport Bile Acid Metabolic Process Fatty Acid Transport Long-chain Fatty Acid Transport Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Very Long-chain Fatty Acid Catabolic Process Long-chain Fatty Acid Import Into Cell Fatty-acyl-CoA Biosynthetic Process Methyl-branched Fatty Acid Metabolic Process
Pathways		Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Ca2+ pathway Ca2+ pathway	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Alpha-oxidation of phytanate Beta-oxidation of very long chain fatty acids Neutrophil degranulation Fatty acyl-CoA biosynthesis Peroxisomal protein import Peroxisomal protein import
Drugs		Sildenafil Tadalafil Vardenafil 3-isobutyl-1-methyl-7H-xanthine
Diseases		Retinitis pigmentosa (RP)
GWAS		Blond vs. brown/black hair color ( 30531825) High myopia ( 31816047) Refractive error ( 32231278)	Platelet count ( 32888494) Verbal declarative memory ( 25648963)
Interacting Genes		11 interacting genes: BHLHE40 DNM2 FNBP1 GNAO1 GRB2 GRK2 L3MBTL3 MAPK3 PRKAB2 SRC TRIP10	4 interacting genes: ABCD1 PEX5 UBC YWHAQ
Entrez ID		5148	11001
HPRD ID		08914	11935
Ensembl ID		ENSG00000185527	ENSG00000140284
Uniprot IDs		P18545	O14975
PDB IDs		3JWR
Enriched GO Terms of Interacting Partners?		Import Into Cell Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Receptor Internalization ERBB Signaling Pathway Vesicle-mediated Transport Actin Cytoskeleton Organization Schwann Cell Development Regulation Of Early Endosome To Late Endosome Transport Contractile Actin Filament Bundle Assembly Stress Fiber Assembly ERBB2 Signaling Pathway Actin Filament-based Process Phagocytic Cup Ephrin Receptor Binding Receptor-mediated Endocytosis Cell Cortex Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Heart Contraction Signal Transduction Podosome Negative Regulation Of Immune Response Protein Domain Specific Binding T Cell Costimulation Phosphotyrosine Residue Binding Nucleotide Binding Peptidyl-tyrosine Phosphorylation Plasma Membrane Negative Regulation Of Relaxation Of Smooth Muscle Regulation Of Blood Circulation Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Guanyl-nucleotide Exchange Factor Adaptor Activity Cellular Response To Nutrient Levels Actin Filament Bundle Assembly Glial Cell Development TORC1 Signaling Actin Filament Bundle Organization Negative Regulation Of TORC1 Signaling Autophagy Clathrin-coated Pit Caveola Edg-2 Lysophosphatidic Acid Receptor Binding Negative Regulation Of Membrane Tubulation Vesicle Scission Mu-type Opioid Receptor Binding Insulin Receptor Signaling Pathway Grb2-EGFR Complex Pristanate-CoA Ligase Activity Phytanate-CoA Ligase Activity Cholate-CoA Ligase Activity	Protein Targeting
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