DTYMK and FZR1

Number of citations of the paper that reports this interaction (PubMedID 16103219)
41

Data Source:
BioGRID (enzymatic study)

		DTYMK	FZR1
Description		deoxythymidylate kinase	fizzy and cell division cycle 20 related 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Cytosol Nuclear Membrane
	Molecular Function	Nucleotide Binding Nucleoside Diphosphate Kinase Activity DTMP Kinase Activity ATP Binding Kinase Activity Transferase Activity	Protein Binding Anaphase-promoting Complex Binding Ubiquitin-protein Transferase Activator Activity Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Activator Activity
	Biological Process	DUDP Biosynthetic Process DTDP Biosynthetic Process DTTP Biosynthetic Process Nucleotide Biosynthetic Process Thymidine Biosynthetic Process Cellular Response To Growth Factor Stimulus	DNA Repair DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Meiotic Nuclear Division Thymidine Biosynthetic Process Cell Division Regulation Of Meiotic Cell Cycle Proteolysis Involved In Protein Catabolic Process Lens Fiber Cell Differentiation Protein K11-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity DNA Synthesis Involved In Mitotic DNA Replication Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of Cellular Senescence
Pathways		Interconversion of nucleotide di- and triphosphates	Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of Emi1 Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Thymidine monophosphate 2',3'-Dideoxythymidine-5'-Monophosphate 3'-Fluoro-3'-deoxythymidine 5'-monophosphate 3'-deoxy-3'-aminothymidine monophosphate p1-(5'-adenosyl)p5-(5'-thymidyl)pentaphosphate Zidovudine monophosphate P1-(5'-Adenosyl)P5-(5'-(3'azido-3'-Deoxythymidyl))Pentaphosphate Phosphoaminophosphonic Acid-Adenylate Ester
Diseases
GWAS		Asthma ( 31959851) Diverticular disease ( 30177863) Prostate cancer ( 23535732)	Red cell distribution width ( 32888494)
Interacting Genes		4 interacting genes: CDC20 CEBPA FZR1 HSD17B7	95 interacting genes: AKT1S1 ANAPC1 ANAPC11 ANAPC2 ANAPC7 ANLN ARNT BECN1 BEX1 BLID BTRC C7orf25 CCL5 CCNA1 CCNB1 CCND2 CCNE1 CCNF CDC14A CDC27 CDC6 CDK2 CDK4 CDK5 CDK6 CDKN2B CDR2 CDT1 CLSPN CYP17A1 DCPS DKK3 DNAJA1 DNM1L DTYMK E2F3 EPHA2 EPSTI1 ERBB2 FBXO5 FGFR4 GLIS2 GMNN HECW2 HIF1A ID2 KAT2A KIF18B LATS2 MAD2L2 MAK MAP2K3 MAP2K5 MAP3K5 MAPK8 MET MOAP1 MTA3 MYC NAT2 NEDD9 NEK2 NF2 OTUD7B PAX3 PDGFRA PSMC3IP PTP4A3 PTTG1 RASSF1 RB1 RBBP8 SASS6 SENP2 SIRT1 SIRT2 SKIL SKP2 SMURF1 SOX2 SOX4 SRC STK11 TBK1 TEAD2 TERT THRSP TK1 TTF2 UBC UBE2D1 UBE2D3 UBE2K UHRF1 USP10
Entrez ID		1841	51343
HPRD ID		01773	04687
Ensembl ID		ENSG00000168393	ENSG00000105325
Uniprot IDs		P23919 Q53F55 Q6FGU2	Q9UM11
PDB IDs		1E2D 1E2E 1E2F 1E2G 1E2Q 1E98 1E99 1E9A 1E9B 1E9C 1E9D 1E9E 1E9F 1NMX 1NMY 1NMZ 1NN0 1NN1 1NN3 1NN5 2XX3	4UI9 5L9T 5L9U 8TAR 8TAU 9GAW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Anaphase-promoting Complex Binding Ubiquitin-protein Transferase Activator Activity Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Activator Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Protein Catabolic Process Anaphase-promoting Complex Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Meiotic Nuclear Division Alcohol Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Meiotic Cell Cycle Small Molecule Biosynthetic Process Small Molecule Metabolic Process Regulation Of Protein Metabolic Process Metaphase/anaphase Transition Of Meiosis I RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Methotrexate Positive Regulation Of Catabolic Process Ubiquitin-like Ligase-substrate Adaptor Activity Positive Regulation Of Protein Ubiquitination Cholesterol Metabolic Process Positive Regulation Of Post-translational Protein Modification Histone Deacetylase Binding Sterol Metabolic Process Regeneration Response To Vitamin B2 C/EBP Complex Dihydrofolate Reductase Activity Regulation Of Nuclear Division CHOP-C/EBP Complex Embryonic Organ Development Dihydrofolate Metabolic Process DNA Synthesis Involved In Mitotic DNA Replication Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Protein Metabolic Process Meiotic Cell Cycle Phase Transition	Regulation Of Cell Cycle Regulation Of Cell Cycle Process Cell Division Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nucleoplasm G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Nucleus Regulation Of Primary Metabolic Process Cytoplasm Regulation Of Chromosome Segregation Cytosol Regulation Of Chromosome Organization Regulation Of Sister Chromatid Segregation Regulation Of Metabolic Process Regulation Of Protein Modification Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification Process Negative Regulation Of Cell Cycle Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Kinase Activity Positive Regulation Of Cell Cycle Phase Transition Spindle Protein Kinase Activity Regulation Of Organelle Organization Negative Regulation Of Metabolic Process Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Cycle Process Post-translational Protein Modification Negative Regulation Of Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Cell Population Proliferation Cellular Response To Stress Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Metabolic Process Transferase Activity Positive Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process
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