KLF3 and DVL3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		KLF3	DVL3
Gene Name		Kruppel-like factor 3 (basic)	dishevelled segment polarity protein 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Cytosol
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Metal Ion Binding	Protease Binding Receptor Binding Frizzled Binding Protein Binding Beta-catenin Binding Protein Heterodimerization Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Multicellular Organismal Development Cellular Response To Peptide	Positive Regulation Of Protein Phosphorylation Outflow Tract Septum Morphogenesis Wnt Signaling Pathway Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Via JNK Cascade Response To Drug Positive Regulation Of JUN Kinase Activity Positive Regulation Of Transcription, DNA-templated Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways			disassembly of the destruction complex and recruitment of AXIN to the membrane WNT mediated activation of DVL misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL negative regulation of TCF-dependent signaling by DVL-interacting proteins Signaling by Wnt Signaling by WNT in cancer PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS		Helicobacter pylori serologic status ( 23652523)	Major depressive disorder ( 22472876)
Protein-Protein Interactions		9 interactors: CTBP1 CTBP2 DVL3 EHMT2 FHL3 KDM1A LHX8 SUV39H2 TRAF2	48 interactors: ADAP1 AXIN1 BAHD1 C8orf33 CCNK CSNK1D CSNK1E CSNK2A1 CTNNB1 DAB2 DIDO1 DPPA2 DVL1 ENKD1 FAM13C KAT7 KLF3 KLHL12 LNX1 LRRK2 LY6H MARK2 MATN2 NKD1 NOL12 NXF1 PIK3CB PITX1 PLN PPM1A PPP2CA PRPF3 PSMF1 RPS10 RWDD2B SNX22 STOM SYT6 TNFAIP8L1 UTP3 VANGL1 WT1 YTHDC1 ZBTB48 ZNF264 ZNF408 ZNF512B ZNF697
Entrez ID		51274	1857
HPRD ID		13920	03222
Ensembl ID		ENSG00000109787	ENSG00000161202
Uniprot IDs		P57682	Q92997
PDB IDs
Enriched GO Terms of Interacting Partners?		Peptidyl-lysine Dimethylation Histone Modification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process White Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Histone H3-K9 Methylation Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Viral Genome Replication Chromatin Modification Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Developmental Process Histone H3-K9 Modification Chromatin Organization Regulation Of Binding Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JUN Kinase Activity Chromosome Organization Regulation Of Primitive Erythrocyte Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Regulation Of JUN Kinase Activity Histone Lysine Methylation Cell Differentiation Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Chromosome Organization Peptidyl-lysine Methylation Regulation Of Metabolic Process Transcription, DNA-templated Regulation Of Embryonic Development Histone Methylation Positive Regulation Of Binding RNA Biosynthetic Process Positive Regulation Of JNK Cascade Fat Cell Differentiation Regulation Of Histone Modification Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Binding DNA Methylation On Cytosine Within A CG Sequence Regulation Of JNK Cascade Meiotic Nuclear Division Histone H3-K9 Dimethylation	Positive Regulation Of Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway Positive Regulation Of Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Gene Expression RNA Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Wnt Signaling Pathway RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Transcription, DNA-templated Nitrogen Compound Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Cell Morphogenesis Regulation Of Proteolysis Regulation Of Cellular Component Organization Cellular Macromolecule Biosynthetic Process Positive Regulation Of Protein Modification Process Macromolecule Biosynthetic Process Negative Regulation Of Binding Regulation Of Gene Expression Cellular Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Transferase Activity Regulation Of Transcription, DNA-templated Regulation Of Kinase Activity Protein Complex Assembly
Tagcloud ?			achieves adaptor analogous blockade dab2 encouraging erks grb2 igfi igfir influencing insufficient links mek nonredundant pharmacologic postreceptor relied responded sensitization sensitizing sevenless shc son sos synergized tracked unselected
Tagcloud (Difference) ?			achieves adaptor analogous blockade dab2 encouraging erks grb2 igfi igfir influencing insufficient links mek nonredundant pharmacologic postreceptor relied responded sensitization sensitizing sevenless shc son sos synergized tracked unselected
Tagcloud (Intersection) ?