KLF3

Description		KLF transcription factor 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Hemopoiesis Cellular Response To Endothelin
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31959851) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 23850713) Endometriosis or endometrial cancer (pleiotropy) ( 29608257) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Hand grip strength ( 29691431) Helicobacter pylori serologic status ( 23652523) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Relative brain age ( 34098431) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Type 1 diabetes ( 34127860) White blood cell count ( 32888494 27863252)
Interacting Genes		10 interacting genes: CTBP2 DVL3 FHL3 LHX6 LHX8 LSM3 OTX2 SUV39H2 TRAF2 UBE2I
Entrez ID		51274
HPRD ID		13920
Ensembl ID		ENSG00000109787
Uniprot IDs		P57682
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Forebrain Neuron Development Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Transcription Coregulator Binding Central Nervous System Neuron Development TORC2 Complex Disassembly SUMO Conjugating Enzyme Activity Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Neuron Differentiation TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding U6 SnRNA 3'-end Binding Sphingolipid Binding IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex RING-like Zinc Finger Domain Binding SUMO Ligase Complex HLH Domain Binding Cerebral Cortex Tangential Migration Histone H3K9 Trimethyltransferase Activity Regulation Of Macromolecule Metabolic Process Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction CD27 Signaling Pathway Small Protein Activating Enzyme Binding Lsm1-7-Pat1 Complex Regulation Of JNK Cascade Regulation Of Metabolic Process Positive Regulation Of Neuron Projection Arborization Eukaryotic Initiation Factor 4E Binding Sequence-specific Double-stranded DNA Binding Positive Regulation Of Gastrulation Tumor Necrosis Factor Binding Tumor Necrosis Factor Receptor Superfamily Binding Cerebral Cortex GABAergic Interneuron Migration Interneuron Migration From The Subpallium To The Cortex Neuron Development Lsm2-8 Complex
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