PDZD11 and EDEM1

		PDZD11	EDEM1
Description		PDZ domain containing 11	ER degradation enhancing alpha-mannosidase like protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Membrane Basolateral Plasma Membrane Pore Complex Anchoring Junction Presynapse	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Aggresome Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Mannosyl-oligosaccharide 1,2-alpha-mannosidase Activity Calcium Ion Binding Protein Binding Misfolded Protein Binding
	Biological Process	Neurotransmitter Secretion Regulation Of Synaptic Assembly At Neuromuscular Junction Pore Complex Assembly Synaptic Vesicle Transport	Carbohydrate Metabolic Process Ubiquitin-dependent Protein Catabolic Process Response To Unfolded Protein Glycoprotein Metabolic Process ERAD Pathway Protein Targeting To ER Positive Regulation Of Retrograde Protein Transport, ER To Cytosol Endoplasmic Reticulum Mannose Trimming
Pathways		Biotin transport and metabolism Vitamin B5 (pantothenate) metabolism Transport of vitamins, nucleosides, and related molecules Ion influx/efflux at host-pathogen interface Ion transport by P-type ATPases	XBP1(S) activates chaperone genes ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS			Alzheimer's disease ( 33074286) Diverticular disease ( 30177863) Liver enzyme levels (alkaline phosphatase) ( 33972514) Metabolite levels ( 23823483) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Uterine fibroids ( 28836065)
Interacting Genes		4 interacting genes: ATP2B2 ATP7A MAGI2 SIGMAR1	1 interacting genes: CANX
Entrez ID		51248	9695
HPRD ID		06622	09644
Ensembl ID		ENSG00000120509	ENSG00000134109
Uniprot IDs		Q5EBL8	Q92611
PDB IDs
Enriched GO Terms of Interacting Partners?			Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Melanosome Membrane Secretion By Cell Protein Folding In Endoplasmic Reticulum Secretion Presynapse Positive Regulation Of Lymphocyte Activation Nucleosome Disassembly BBAF Complex Brahma Complex NBAF Complex Protein-DNA Complex Disassembly Regulation Of Lymphocyte Activation NpBAF Complex Positive Regulation Of Cell Activation Regulation Of Fatty Acid Beta-oxidation Phosphatidylinositol 3-kinase Binding Negative Regulation Of B Cell Apoptotic Process Protein-macromolecule Adaptor Activity Type B Pancreatic Cell Proliferation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Fatty Acid Beta-oxidation Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Phosphatidylinositol 3-kinase Activator Activity Insulin Receptor Binding Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Regulation Of B Cell Apoptotic Process Positive Regulation Of Type B Pancreatic Cell Proliferation Positive Regulation Of Fatty Acid Oxidation Response To Endothelin Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Cellular Response To Endothelin Pore Complex Regulation Of Synaptic Assembly At Neuromuscular Junction Pore Complex Assembly
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