CHD2 and ZNF398

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CHD2	ZNF398
Description		chromodomain helicase DNA binding protein 2	zinc finger protein 398
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus
	Molecular Function	Nucleotide Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding RNA Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Histone Binding ATP-dependent Chromatin Remodeler Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Chromatin Organization Chromatin Remodeling DNA Damage Response Muscle Organ Development Gene Expression Nucleosome Organization Hematopoietic Stem Cell Differentiation	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription
Pathways			Generic Transcription Pathway
Drugs
Diseases
GWAS		Adolescent idiopathic scoliosis ( 30395268) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Daytime nap ( 33568662) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Pulse pressure ( 30224653)	Eosinophil count ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		11 interacting genes: BEND7 ELOA2 MEOX2 MID2 SRPK2 TEKT1 THAP1 TRIM41 TRIM54 TULP3 ZNF398	22 interacting genes: - AIRIM AQP1 CABP5 CHD2 CIB3 CLK2 DGCR6 ELMO1 EMD ESR1 GPATCH2L MAGOHB MFAP1 NCDN NDE1 NUDT22 OPTN PLEKHF2 SMARCB1 TRIM41 ZNF783
Entrez ID		1106	57541
HPRD ID		03669	18336
Ensembl ID		ENSG00000173575	ENSG00000197024
Uniprot IDs		O14647	A0A090N7S8 A0A090N8F2 B4DXA9 Q8TD17
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Skeletal Muscle Tissue Development Negative Regulation Of Endothelial Cell Migration Limb Development Regulation Of RNA Metabolic Process Innate Immune Response Defense Response To Other Organism Negative Regulation Of Viral Process Defense Response To Symbiont Zinc Ion Binding Radial Pattern Formation Bronchus Morphogenesis Microtubule Ubiquitin Protein Ligase Activity
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