DCXR and CRADD

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		DCXR	CRADD
Name		dicarbonyl and L-xylulose reductase	CARD and death domain containing adaptor protein
Structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Cytosol Cytoplasmic Microtubule Plasma Membrane Microvillus Brush Border Membrane Extracellular Exosome	Nucleus Nucleolus Cytoplasm Cytosol Endopeptidase Complex
	Molecular Function	Carbonyl Reductase (NADPH) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On CH-OH Group Of Donors Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Identical Protein Binding L-xylulose Reductase (NADPH) Activity	Protease Binding Protein Binding Protein-macromolecule Adaptor Activity Death Domain Binding
	Biological Process	Xylulose Metabolic Process Glucose Metabolic Process NADP+ Metabolic Process D-glucuronate Catabolic Process To D-xylulose 5-phosphate D-xylose Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	Apoptotic Process DNA Damage Response Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Formation of xylulose-5-phosphate Essential pentosuria	TP53 Regulates Transcription of Caspase Activators and Caspases
Drugs		Dihydrogenphosphate Nicotinamide adenine dinucleotide phosphate	None
Diseases		Pentosuria	None
GWAS		Refractive error ( 32231278 )	Alzheimer's disease (cognitive decline) ( 23535033 ) Appendicular lean mass ( 33097823 ) Asthma ( 31959851 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Heel bone mineral density ( 28869591 30598549 ) Height ( 31562340 33713608 18391951 31217584 28552196 25282103 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Hip circumference adjusted for BMI ( 25673412 34021172 ) Lung function (FVC) ( 30804560 30061609 ) Pulse pressure ( 27841878 ) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309 ) Reticulocyte count ( 32888494 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Novel Interactors		1 novel interactors: RPTOR	None recorded
Interacting Genes		4 interacting genes: APP CEBPA CRADD GLRX2	22 interacting genes: ACTN2 APP APPL2 BBS5 CASP2 CASP8 CCSER2 DCXR EEF1A1 ERG28 IL9R KCTD9 KPNA1 LRIF1 PIDD1 PTGER4 RIPK1 SLC35A3 TRIM54 TSHR VTN WIF1
Entrez ID		51181	8738
HPRD ID		16320	04584
Ensembl ID		ENSG00000169738	ENSG00000169372
Uniprot IDs		A0A384NY14 Q7Z4W1	B4DJT6 F5H7C2 F8VV49 F8VVY5 P78560 Q53XL1 Q8IY43
PDB IDs		1PR9 1WNT 3D3W	2O71 2OF5 3CRD
GO Terms Enriched among Interactors		Positive Regulation Of Glycolytic Process Positive Regulation Of ATP Metabolic Process Regulation Of Glycolytic Process Homeostatic Process Regulation Of Carbohydrate Catabolic Process Amyloid-beta Complex Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Response To Stress Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of Toll Signaling Pathway RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Arsenate Reductase (glutaredoxin) Activity Positive Regulation Of Catabolic Process Cellular Response To Stress Notch Signaling Pathway Acetylcholine Receptor Activator Activity Positive Regulation Of Mitotic Cell Cycle Intracellular Signal Transduction Cellular Homeostasis Lipoprotein Particle Memory Positive Regulation Of Protein Import Regulation Of Generation Of Precursor Metabolites And Energy Response To Vitamin B2 C/EBP Complex Glutathione Disulfide Oxidoreductase Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Cell Maturation Positive Regulation Of Endothelin Production Positive Regulation Of Apoptotic Signaling Pathway Growth Cone Filopodium Positive Regulation Of Small Molecule Metabolic Process Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization CHOP-C/EBP Complex Death Domain Binding Endopeptidase Complex Positive Regulation Of Proteolysis Apoptotic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Chemical Homeostasis Intermediate-density Lipoprotein Particle	Positive Regulation Of Neuron Apoptotic Process Death Receptor Binding Endopeptidase Complex Extrinsic Apoptotic Signaling Pathway Signal Transduction Identical Protein Binding Ripoptosome Death-inducing Signaling Complex Positive Regulation Of Inflammatory Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Response To Mechanical Stimulus Cellular Response To Mechanical Stimulus Positive Regulation Of Macrophage Differentiation Negative Regulation Of Necroptotic Process Regulation Of Neuron Apoptotic Process Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Programmed Necrotic Cell Death Cellular Response To Growth Factor Stimulus Execution Phase Of Apoptosis Regulation Of Macrophage Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Regulation Of Reactive Oxygen Species Metabolic Process Amyloid Fibril Formation Apoptotic Signaling Pathway Regulation Of Necroptotic Process Integrin Binding Actin Filament Uncapping Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Endocytosis Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Protein-containing Complex Binding Regulation Of Programmed Necrotic Cell Death Interleukin-9 Binding Interleukin-9 Receptor Activity Negative Regulation Of Eosinophil Extravasation Cellular Response To Thyrotropin-releasing Hormone Symbiont-containing Vacuole L-xylulose Reductase (NADPH) Activity Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Supramolecular Fiber Organization Regulation Of Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors