DCXR

Name	dicarbonyl and L-xylulose reductase
Structure
Novel Interactors	1 novel interactors: RPTOR
Interactors	4 interactors: APP CEBPA CRADD GLRX2
GO Annotations	Cellular Component	Nucleus Mitochondrion Cytosol Cytoplasmic Microtubule Plasma Membrane Microvillus Brush Border Membrane Extracellular Exosome
	Molecular Function	Carbonyl Reductase (NADPH) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On CH-OH Group Of Donors Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Identical Protein Binding L-xylulose Reductase (NADPH) Activity
	Biological Process	Xylulose Metabolic Process Glucose Metabolic Process NADP+ Metabolic Process D-glucuronate Catabolic Process To D-xylulose 5-phosphate D-xylose Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways	Formation of xylulose-5-phosphate Essential pentosuria
Drugs	Dihydrogenphosphate Nicotinamide adenine dinucleotide phosphate
Diseases	Pentosuria
GWAS	Refractive error ( 32231278 )
Entrez ID	51181
HPRD ID	16320
Ensembl ID	ENSG00000169738
Uniprot IDs	A0A384NY14 Q7Z4W1
PDB IDs	1PR9 1WNT 3D3W
GO Terms Enriched among Interactors ?	Positive Regulation Of Glycolytic Process Positive Regulation Of ATP Metabolic Process Regulation Of Glycolytic Process Homeostatic Process Regulation Of Carbohydrate Catabolic Process Amyloid-beta Complex Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Response To Stress Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of Toll Signaling Pathway RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Arsenate Reductase (glutaredoxin) Activity Positive Regulation Of Catabolic Process Cellular Response To Stress Notch Signaling Pathway Acetylcholine Receptor Activator Activity Positive Regulation Of Mitotic Cell Cycle Intracellular Signal Transduction Cellular Homeostasis Lipoprotein Particle Memory Positive Regulation Of Protein Import Regulation Of Generation Of Precursor Metabolites And Energy Response To Vitamin B2 C/EBP Complex Glutathione Disulfide Oxidoreductase Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Cell Maturation Positive Regulation Of Endothelin Production Positive Regulation Of Apoptotic Signaling Pathway Growth Cone Filopodium Positive Regulation Of Small Molecule Metabolic Process Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization CHOP-C/EBP Complex Death Domain Binding Endopeptidase Complex Positive Regulation Of Proteolysis Apoptotic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Chemical Homeostasis Intermediate-density Lipoprotein Particle