COQ7 and COQ4

Number of citations: 55 (PubMedID 27499296)
Data Source: BioGRID (pull down)

		COQ7	COQ4
Name		coenzyme Q7, hydroxylase	coenzyme Q4
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Chromosome Mitochondrion Mitochondrial Inner Membrane Membrane Extrinsic Component Of Mitochondrial Inner Membrane Ubiquinone Biosynthesis Complex	Mitochondrion Mitochondrial Inner Membrane Membrane Extrinsic Component Of Mitochondrial Inner Membrane Protein-containing Complex Ubiquinone Biosynthesis Complex
	Molecular Function	Chromatin Binding Monooxygenase Activity Protein Binding 3-demethoxyubiquinol 3-hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Metal Ion Binding 3-demethoxyubiquinone 3-hydroxylase (NADH) Activity	Protein Binding Lyase Activity 4-hydroxy-3-methoxy-5-polyprenylbenzoate Decarboxylase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ubiquinone Biosynthetic Process Determination Of Adult Lifespan Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Reactive Oxygen Species Metabolic Process	Ubiquinone Biosynthetic Process
Pathways		Ubiquinol biosynthesis	Ubiquinol biosynthesis
GWAS		Parkinson's disease ( 28892059 )	Body mass index ( 26426971 ) Obesity-related traits ( 23251661 )
Novel Interactors		1 novel interactors: CPPED1	None recorded
Interacting Genes		1 interacting genes: COQ4	4 interacting genes: COQ7 COQ9 MAGEA2 MAGEA2B
Entrez ID		10229	51117
HPRD ID		03401	16741
Ensembl ID		ENSG00000167186	ENSG00000167113
Uniprot IDs		Q99807	Q9Y3A0
PDB IDs		7SSP 7SSS	Not available
GO Terms Enriched among Interactors		4-hydroxy-3-methoxy-5-polyprenylbenzoate Decarboxylase Activity Extrinsic Component Of Mitochondrial Inner Membrane Ubiquinone Biosynthesis Complex Ubiquinone Metabolic Process Ubiquinone Biosynthetic Process Quinone Metabolic Process Ketone Biosynthetic Process Ketone Metabolic Process Protein Serine/threonine Phosphatase Activity Azurophil Granule Lumen Lyase Activity	Negative Regulation Of Protein Acetylation Ubiquinone Biosynthesis Complex Negative Regulation Of Protein Sumoylation Positive Regulation Of Ubiquitin-protein Transferase Activity Ubiquinone Biosynthetic Process Ubiquinone Metabolic Process Quinone Metabolic Process Regulation Of Protein Sumoylation Regulation Of Ubiquitin-protein Transferase Activity Ketone Biosynthetic Process Cellular Senescence Ketone Metabolic Process Negative Regulation Of Post-translational Protein Modification Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination PML Body 3-demethoxyubiquinol 3-hydroxylase Activity 3-demethoxyubiquinone 3-hydroxylase (NADH) Activity Isoprenoid Binding Positive Regulation Of Post-translational Protein Modification Histone Deacetylase Binding DNA-binding Transcription Factor Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Extrinsic Component Of Mitochondrial Inner Membrane Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Catalytic Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Modification Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Mitochondrial Inner Membrane Small Molecule Biosynthetic Process Regulation Of Catalytic Activity Negative Regulation Of Protein Metabolic Process Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Modification Process Determination Of Adult Lifespan Negative Regulation Of Biosynthetic Process Mitochondrial Electron Transport, NADH To Ubiquinone Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process Monooxygenase Activity Aerobic Electron Transport Chain