TPRKB and TP53RK

Number of citations of the paper that reports this interaction (PMID 23455922)
9

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro, two hybrid)

		TPRKB	TP53RK
Gene Name		TP53RK binding protein	TP53 regulating kinase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	EKC/KEOPS Complex Nucleus Cytosol Membrane
	Molecular Function	Protein Binding Protein Kinase Binding	P53 Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Hydrolase Activity
	Biological Process	TRNA Processing	Protein Phosphorylation TRNA Processing Threonylcarbamoyladenosine Metabolic Process
Pathways
Drugs
Diseases
GWAS		Creatinine levels ( 20383145) Metabolite levels ( 21931564)
Protein-Protein Interactions		2 interactors: TP53RK TRIM27	4 interactors: CALCOCO2 MTUS2 TP53 TPRKB
Entrez ID		51002	112858
HPRD ID		12277	12276
Ensembl ID		ENSG00000144034	ENSG00000172315
Uniprot IDs		Q9Y3C4	Q5JZ02 Q96S44
PDB IDs		3ENP
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Interleukin-2 Secretion Threonylcarbamoyladenosine Metabolic Process Negative Regulation Of Calcium Ion Import Interferon-gamma Secretion Adenosine Metabolic Process Negative Regulation Of Viral Release From Host Cell Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Viral Transcription Regulation Of Viral Release From Host Cell Regulation Of Calcium Ion Import Protein K63-linked Ubiquitination Cytokine Secretion Protein Trimerization Negative Regulation Of Cytokine Secretion Negative Regulation Of Adaptive Immune Response Protein Phosphorylation Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Negative Regulation Of Calcium Ion Transport Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Actin Nucleation Retrograde Transport, Endosome To Golgi Regulation Of Viral Transcription Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Viral Process Phosphorylation	Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Negative Regulation Of Helicase Activity Positive Regulation Of Cell Aging Positive Regulation Of Thymocyte Apoptotic Process Mitochondrial DNA Repair Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment Glial Cell Apoptotic Process Oxidative Stress-induced Premature Senescence ER Overload Response Negative Regulation Of Macroautophagy Stress-induced Premature Senescence Positive Regulation Of T Cell Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Strand Renaturation Viral Process DNA Damage Response, Signal Transduction Resulting In Transcription Mitotic Cell Cycle Arrest Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Thymocyte Apoptotic Process Replicative Senescence Positive Regulation Of Mitochondrial Membrane Permeability Determination Of Adult Lifespan Positive Regulation Of Lymphocyte Apoptotic Process Circadian Behavior Mitochondrial DNA Metabolic Process Positive Regulation Of Histone Deacetylation Rhythmic Behavior Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Protein Oligomerization Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process RRNA Transcription T Cell Lineage Commitment Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Entrainment Of Circadian Clock By Photoperiod Positive Regulation Of Protein Deacetylation Cellular Response To Glucose Starvation Positive Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Neuroblast Proliferation Photoperiodism Entrainment Of Circadian Clock Protein Import Into Nucleus, Translocation Regulation Of Protein Oligomerization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Mitochondrial Genome Maintenance Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Necroptotic Process
Tagcloud ?		atxn2 bid ccnf cdkn1a cntn4 dcp1b dysregulations granule granules haploinsufficiency hnrnpa1 hnrnpa2b1 immunoblots inca1 mapt noteworthy nucleator plin4 pnpla2 prioritized smn tardbp tbc1d24 tia tia1 tial1 translocate upregulations wdfy1
Tagcloud (Difference) ?		atxn2 bid ccnf cdkn1a cntn4 dcp1b dysregulations granule granules haploinsufficiency hnrnpa1 hnrnpa2b1 immunoblots inca1 mapt noteworthy nucleator plin4 pnpla2 prioritized smn tardbp tbc1d24 tia tia1 tial1 translocate upregulations wdfy1
Tagcloud (Intersection) ?