TYSND1 and TH

Number of citations of the paper that reports this interaction (PubMedID 22002062)
71

Data Source:
BioGRID (enzymatic study)

		TYSND1	TH
Description		trypsin like peroxisomal matrix peptidase 1	tyrosine hydroxylase
Image		No pdb structure
GO Annotations	Cellular Component	Peroxisome Peroxisomal Matrix Cytosol Membrane	Nucleus Cytoplasm Smooth Endoplasmic Reticulum Cytosol Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Axon Cytoplasmic Vesicle Melanosome Membrane Cell Projection Neuron Projection Perikaryon Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Protease Binding Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding	Monooxygenase Activity Tyrosine 3-monooxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Pteridine As One Donor, And Incorporation Of One Atom Of Oxygen Enzyme Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Proteolysis Protein Processing Regulation Of Fatty Acid Beta-oxidation	Response To Hypoxia Synaptic Transmission, Dopaminergic Heart Morphogenesis Dopamine Biosynthetic Process From Tyrosine Heart Development Visual Perception Learning Memory Mating Behavior Locomotory Behavior Regulation Of Heart Contraction Aromatic Amino Acid Metabolic Process Anatomical Structure Morphogenesis Animal Organ Morphogenesis Dopamine Biosynthetic Process Epinephrine Biosynthetic Process Norepinephrine Biosynthetic Process Catecholamine Biosynthetic Process Serotonin Biosynthetic Process Eye Photoreceptor Cell Development Eating Behavior Pigmentation Response To Ethanol Embryonic Camera-type Eye Morphogenesis Cognition Hyaloid Vascular Plexus Regression
Pathways		Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins TYSND1 cleaves peroxisomal proteins	Catecholamine biosynthesis
Drugs			Phenylalanine Tyrosine Sapropterin Metyrosine 3-Tyrosine L-erythro-7,8-dihydrobiopterin
Diseases			Primary torsion dystonia (PTD)
GWAS			Celiac disease ( 23936387) Height ( 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) Iron status biomarkers (ferritin levels) ( 33536631) Prostate cancer ( 19767753) Prostate cancer (early onset) ( 24740154) Prostate cancer (SNP x SNP interaction) ( 22219177) Severe autoimmune type 2 diabetes ( 34737425) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Type 1 diabetes in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 25102180 31324766)
Interacting Genes		3 interacting genes: ACOX1 TH UBC	22 interacting genes: CAMK2G CDK11B CRABP1 CSNK2A1 DAAM2 HNRNPK MAPK1 MAPK3 MAPKAPK2 MDFI PIAS2 PRKACA PUF60 RBMY1A1 RPS6KA5 SNCA TSPYL4 TYSND1 UMAD1 YWHAB YWHAZ ZNF569
Entrez ID		219743	7054
HPRD ID		15593	01865
Ensembl ID		ENSG00000156521	ENSG00000180176
Uniprot IDs		Q2T9J0	P07101 P78428
PDB IDs			2XSN 4J6S 6ZN2 6ZVP 6ZZU 7A2G 7PIM
Enriched GO Terms of Interacting Partners?		Very Long-chain Fatty Acid Beta-oxidation Tyrosine 3-monooxygenase Activity Dopamine Biosynthetic Process From Tyrosine Long-chain Fatty Acyl-CoA Oxidase Activity Acyl-CoA Oxidase Activity Serotonin Biosynthetic Process Epinephrine Biosynthetic Process Epinephrine Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Pteridine As One Donor, And Incorporation Of One Atom Of Oxygen Hyaloid Vascular Plexus Regression Very Long-chain Fatty Acid Catabolic Process Norepinephrine Biosynthetic Process Reactive Oxygen Species Biosynthetic Process Alpha-linolenic Acid Metabolic Process Hydrogen Peroxide Biosynthetic Process Peroxisome Fission Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Synaptic Transmission, Dopaminergic Serotonin Metabolic Process Anatomical Structure Regression Dopamine Biosynthetic Process Norepinephrine Metabolic Process Embryonic Camera-type Eye Morphogenesis Tyrosine Metabolic Process Protein Tag Activity Catecholamine Biosynthetic Process Smooth Endoplasmic Reticulum Mating Behavior Melanosome Membrane Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Oxidoreductase Activity Fatty Acid Binding Prostanoid Metabolic Process Hydrogen Peroxide Metabolic Process Very Long-chain Fatty Acid Metabolic Process Prostaglandin Metabolic Process Amine Biosynthetic Process Eating Behavior Eye Photoreceptor Cell Development Biogenic Amine Biosynthetic Process Reproductive Behavior Embryonic Eye Morphogenesis Dopamine Metabolic Process Long-chain Fatty Acid Biosynthetic Process Aromatic Amino Acid Metabolic Process Photoreceptor Cell Development FAD Binding Organic Acid Metabolic Process Carboxylic Acid Metabolic Process Unsaturated Fatty Acid Biosynthetic Process	Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein Serine Kinase Activity Regulation Of Primary Metabolic Process Protein Serine/threonine Kinase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Sequestering Activity Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Protein Kinase Activity TORC1 Signaling Interleukin-34-mediated Signaling Pathway Kinase Activity Negative Regulation Of Macromolecule Metabolic Process TOR Signaling Regulation Of Golgi Inheritance Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Protein Phosphorylation Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Regulation Of Protein Stability Phosphoserine Residue Binding Protein Domain Specific Binding Negative Regulation Of Catabolic Process Phosphorylation Regulation Of Multicellular Organismal Process Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Regulation Of Signal Transduction Phosphotyrosine Residue Binding Regulation Of Cell Communication Regulation Of Signaling Regulation Of MRNA Processing Focal Adhesion Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Long-term Synaptic Potentiation Nucleus ERK1 And ERK2 Cascade Bergmann Glial Cell Differentiation Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Epinephrine Stimulus
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?