AIRE

Description		autoimmune regulator
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GO Annotations	Cellular Component	Male Germ Cell Nucleus Female Germ Cell Nucleus Nucleus Cytoplasm Nuclear Body
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Identical Protein Binding Translation Regulator Activity Metal Ion Binding
	Biological Process	Peripheral T Cell Tolerance Induction Tolerance Induction Central Tolerance Induction To Self Antigen Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Regulation Of Translation Immune Response Humoral Immune Response Positive Regulation Of Chemokine Production Negative Thymic T Cell Selection Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Thymus Epithelium Morphogenesis Regulation Of Thymocyte Migration
Pathways
Drugs
Diseases		Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Addison's disease ( 33574239) Dental caries (decayed, missing and filled teeth) ( 31533690) Rheumatoid arthritis ( 21505073 30423114) Type 1 diabetes ( 34012112)
Novel Interacting Genes		1 novel interacting genes: PTTG1IP
Interacting Genes		8 interacting genes: ATP5F1A CREBBP DAXX H2BC21 H3C1 HEXB PICK1 UBAC1
Entrez ID		326
HPRD ID		06301
Ensembl ID		ENSG00000160224
Uniprot IDs		O43918
PDB IDs		1XWH 2KE1 2KFT 2LRI
Enriched GO Terms of Interacting Partners?		P53 Binding Nucleosome Assembly Nucleosome Organization Protein-DNA Complex Assembly Extracellular Exosome Chromatin Remodeling Adenyl Ribonucleotide Binding Beta-N-acetylglucosaminidase Activity Male Courtship Behavior Chromatin Organization Histone H3K27 Acetyltransferase Activity Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Cellular Response To Diamide Beta-N-acetylhexosaminidase Complex Structural Constituent Of Chromatin Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Chondroitin Sulfate Proteoglycan Catabolic Process Hexosaminidase Activity Nucleosome
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