CHST1

Gene Name		carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Integral Component Of Membrane
	Molecular Function	Sulfotransferase Activity Keratan Sulfotransferase Activity
	Biological Process	Carbohydrate Metabolic Process Polysaccharide Metabolic Process Galactose Metabolic Process Sulfur Compound Metabolic Process Inflammatory Response Pathogenesis Keratan Sulfate Biosynthetic Process Glycosaminoglycan Metabolic Process Keratan Sulfate Metabolic Process Small Molecule Metabolic Process
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome Keratan sulfate/keratin metabolism MPS IX - Natowicz syndrome Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Glycogen storage diseases Defective CHST6 causes MCDC1 MPS IIID - Sanfilippo syndrome D MPS IIIC - Sanfilippo syndrome C Keratan sulfate biosynthesis Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Metabolism of carbohydrates MPS VII - Sly syndrome MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: NHP2L1 SFN
Entrez ID		8534
HPRD ID		07051
Ensembl ID
Uniprot IDs		O43916
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Epidermal Cell Division Keratinocyte Development Negative Regulation Of Keratinocyte Proliferation Positive Regulation Of Protein Export From Nucleus Establishment Of Skin Barrier Regulation Of Water Loss Via Skin Positive Regulation Of Epidermal Cell Differentiation Regulation Of Keratinocyte Proliferation Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Regulation Of Protein Export From Nucleus Release Of Cytochrome C From Mitochondria Positive Regulation Of Epidermis Development Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Epidermal Cell Differentiation Keratinization Multicellular Organismal Water Homeostasis Positive Regulation Of Mitochondrion Organization Water Homeostasis Regulation Of Epidermis Development Apoptotic Mitochondrial Changes Positive Regulation Of Epithelial Cell Differentiation Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Keratinocyte Differentiation Regulation Of Mitochondrion Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity RNA Phosphodiester Bond Hydrolysis Positive Regulation Of Nucleocytoplasmic Transport
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