NAP1L3 and USP25

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		NAP1L3	USP25
Description		nucleosome assembly protein 1 like 3	ubiquitin specific peptidase 25
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol
	Molecular Function	Chromatin Binding Protein Binding Histone Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin-like Protein Peptidase Activity Ubiquitin Protein Ligase Binding SUMO Binding Ubiquitin Binding ATPase Binding Deubiquitinase Activity
	Biological Process	Nucleosome Assembly	Proteolysis Protein Deubiquitination Regulation Of Protein Stability Cellular Response To Oxidative Stress Protein Modification Process Interleukin-17A-mediated Signaling Pathway Protein K63-linked Deubiquitination Protein K48-linked Ubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Response To Oxidative Stress Negative Regulation Of Interleukin-17-mediated Signaling Pathway Negative Regulation Of ERAD Pathway
Pathways			Ub-specific processing proteases
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Crohn's disease ( 25489960) Metabolite levels ( 23823483) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Panic disorder ( 19165232) Parkinson's disease ( 21738487) QRS complex (12-leadsum) ( 27659466) Serum alkaline phosphatase levels ( 33547301) Severe autoimmune type 2 diabetes ( 34737425) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		3 interacting genes: BEND7 TSPYL4 USP25	37 interacting genes: ACTA1 ARMC8 CDC73 CNTN1 EIF4A3 FBXL17 FLNC GAPDH GDI1 MAGEB4 MAVS MID2 MT2A NAP1L3 PAX6 PUS10 RAD23A RAD23B RPS10-NUDT3 RSL1D1 SENP1 SKIL SNRNP70 SUMO1 SUMO2 SUMO3 SYK TMEM43 TNKS TNKS2 TUBB UBC UBE2I VPS45 YARS1 ZNF426 ZNF841
Entrez ID		4675	29761
HPRD ID		02123	05296
Ensembl ID		ENSG00000186310	ENSG00000155313
Uniprot IDs		Q8IYV1 Q99457	Q9UHP3
PDB IDs			2MUX 5GP7 5O71 6H4J 6H4K 6HEL 6HEM
Enriched GO Terms of Interacting Partners?		Glycosylceramide Catabolic Process Negative Regulation Of Nitric-oxide Synthase Activity Regulation Of Nitric-oxide Synthase Activity Glycoside Catabolic Process Alpha-galactosidase Activity Negative Regulation Of Interleukin-17-mediated Signaling Pathway Ubiquitin-like Protein Peptidase Activity Interleukin-17A-mediated Signaling Pathway Negative Regulation Of ERAD Pathway Negative Regulation Of Oxidoreductase Activity Negative Regulation Of Response To Oxidative Stress SUMO Binding Glycosylceramide Metabolic Process Glycosphingolipid Catabolic Process Ceramide Catabolic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Oxidoreductase Activity Glycolipid Catabolic Process Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Protein K63-linked Deubiquitination Regulation Of ERAD Pathway Deubiquitinase Activity Protein K48-linked Deubiquitination Regulation Of Response To Oxidative Stress Sphingolipid Catabolic Process	Presynaptic Cytosol Protein Tag Activity Protein Sumoylation Postsynaptic Cytosol Nucleus Post-translational Protein Modification Protein Modification By Small Protein Conjugation PML Body Protein Poly-ADP-ribosylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification Process Ubiquitin-like Protein Ligase Binding Macromolecule Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Small Protein Activating Enzyme Binding Positive Regulation Of Telomere Capping Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Glutamatergic Synapse Modification-dependent Protein Catabolic Process Protein Metabolic Process Protein Localization To Chromosome, Telomeric Region Protein Auto-ADP-ribosylation NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity Regulation Of Telomere Capping Protein Localization To Organelle Cytoplasm Positive Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Cytosol Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Proteasome Binding Negative Regulation Of DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin-specific Protease Binding Cellular Response To Cadmium Ion SUMO Transferase Activity Transcription Factor Binding Nuclear Pore NAD+-protein Mono-ADP-ribosyltransferase Activity Positive Regulation Of Type I Interferon Production Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Pericentriolar Material Positive Regulation Of Telomere Maintenance Via Telomerase Response To Cytokine
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