MYF6 and CSRP3

Number of citations of the paper that reports this interaction (PubMedID 9234731)
64

Data Source:
HPRD (in vitro, in vivo)

		MYF6	CSRP3
Description		myogenic factor 6	cysteine and glycine rich protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Mitotic Spindle RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Sarcomere Z Disc
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding	Actin Binding Protein Binding Structural Constituent Of Muscle Telethonin Binding Identical Protein Binding Actinin Binding Metal Ion Binding
	Biological Process	Somitogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Skeletal Muscle Tissue Development Tissue Development Cell Differentiation Skeletal Muscle Cell Differentiation Muscle Cell Fate Commitment Skeletal Muscle Tissue Regeneration Positive Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development Positive Regulation Of Skeletal Muscle Fiber Development Muscle Tissue Morphogenesis	Regulation Of The Force Of Heart Contraction Cardiac Muscle Hypertrophy Intracellular Calcium Ion Homeostasis Inflammatory Response Heart Development Muscle Organ Development Skeletal Muscle Tissue Development Insulin Receptor Signaling Pathway Cell Differentiation T-tubule Organization Protein Localization To Organelle Detection Of Muscle Stretch Glucose Homeostasis Sarcomere Organization Negative Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Muscle Cell Cellular Homeostasis Cardiac Muscle Tissue Development Cardiac Myofibril Assembly Cardiac Muscle Contraction Muscle Tissue Development Establishment Of Protein Localization To Organelle Phospholipase C/protein Kinase C Signal Transduction Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Actin Filament Severing Positive Regulation Of Actin Filament Severing
Pathways		Myogenesis Myogenesis TGFBR3 expression
Drugs
Diseases		Dystrophinopathies, including: Duchenne muscular dystrophy (DMD); Becker muscular dystrophy (BMD); X-linked dilated cardiomyopathy (XLCM)	Hypertrophic cardiomyopathy (HCM)
GWAS			Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Mosquito bite size ( 28199695) Red blood cell count ( 27863252 32888494)
Interacting Genes		10 interacting genes: CALM1 CALM2 CALM3 CSRP3 ID1 ID2 ID3 LAMTOR5 TCF12 TCF3	11 interacting genes: ACTN1 FHL1 HDAC4 LDHD LIMS1 MYF6 MYOD1 MYOG NHLH1 RIN3 SPTB
Entrez ID		4618	8048
HPRD ID		01169	07525
Ensembl ID		ENSG00000111046	ENSG00000129170
Uniprot IDs		P23409	A0A3B3ISZ2 A2TDB8 P50461
PDB IDs			2O10 2O13
Enriched GO Terms of Interacting Partners?		Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Sarcomere Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Protein Dimerization Activity Titin Binding Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Calyx Of Held Catalytic Complex Negative Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Transporter Activity Calcium Channel Complex Calcineurin-mediated Signaling Presynaptic Cytosol BHLH Transcription Factor Binding Myelin Sheath Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Transmembrane Transporter Binding Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of Calcium Ion Transmembrane Transport Protein-containing Complex Transcription Regulator Inhibitor Activity Spindle Microtubule Presynaptic Endocytosis Substantia Nigra Development Calcium Channel Regulator Activity Regulation Of DNA-binding Transcription Factor Activity Sperm Midpiece Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Regulation Of Heart Contraction Long-term Synaptic Potentiation Cell Cycle G2/M Phase Transition Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Neural Nucleus Development Negative Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Cation Transmembrane Transport Protein Serine/threonine Kinase Activator Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Detection Of Stimulus Regulation Of Blood Circulation	Regulation Of Myotube Differentiation Positive Regulation Of Skeletal Muscle Fiber Development Regulation Of Skeletal Muscle Fiber Development Muscle Cell Fate Commitment Positive Regulation Of Striated Muscle Tissue Development Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Skeletal Muscle Tissue Development DNA-binding Transcription Activator Activity Regulation Of Skeletal Muscle Tissue Development Muscle Organ Development Muscle Structure Development Regulation Of Muscle Cell Differentiation Regulation Of Striated Muscle Tissue Development Positive Regulation Of Striated Muscle Cell Differentiation Regulation Of Muscle Organ Development Positive Regulation Of Myoblast Differentiation Protein Dimerization Activity E-box Binding Skeletal Muscle Cell Differentiation Response To Denervation Involved In Regulation Of Muscle Adaptation Skeletal Muscle Tissue Development Response To Muscle Inactivity Cell Differentiation Regulation Of Myoblast Differentiation Positive Regulation Of Muscle Cell Differentiation Response To Inactivity Muscle Cell Development Cellular Developmental Process Striated Muscle Tissue Development Skeletal Muscle Tissue Regeneration Regulation Of Myoblast Fusion Myotube Differentiation Muscle Tissue Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Skeletal Muscle Fiber Development Cell Fate Commitment Myotube Cell Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cellular Response To Estradiol Stimulus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Sequence-specific Double-stranded DNA Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process Tissue Regeneration Cortical Actin Cytoskeleton Negative Regulation Of Mast Cell Chemotaxis D-lactate Dehydrogenase (cytochrome) Activity
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