MSRA and SDHB

Number of citations of the paper that reports this interaction (PubMedID 32456285)
47

Data Source:
BioGRID (two hybrid)

		MSRA	SDHB
Description		methionine sulfoxide reductase A	succinate dehydrogenase complex iron sulfur subunit B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Membrane Nuclear Body Extracellular Exosome	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Plasma Membrane Membrane Mitochondrial Membrane Respiratory Chain Complex II (succinate Dehydrogenase)
	Molecular Function	Protein Binding Peptide-methionine (S)-S-oxide Reductase Activity Oxidoreductase Activity L-methionine:thioredoxin-disulfide S-oxidoreductase Activity L-methionine-(S)-S-oxide Reductase Activity	Protein Binding Succinate Dehydrogenase (quinone) Activity Electron Transfer Activity Oxidoreductase Activity Metal Ion Binding Ubiquinone Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding 3 Iron, 4 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Methionine Metabolic Process Response To Oxidative Stress Protein Repair Cellular Response To Oxidative Stress Protein Modification Process	Tricarboxylic Acid Cycle Succinate Metabolic Process Mitochondrial Electron Transport, Succinate To Ubiquinone Aerobic Respiration Respiratory Electron Transport Chain Proton Motive Force-driven Mitochondrial ATP Synthesis
Pathways		Protein repair	Respiratory electron transport Citric acid cycle (TCA cycle) Maturation of TCA enzymes and regulation of TCA cycle
Drugs		1,4-Dithiothreitol	2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Ubiquinone Q1
Diseases
GWAS		A body shape index ( 34021172) Adiposity ( 19557161) Adult body size ( 32376654) Age at first sexual intercourse ( 27089180) Alzheimer's disease ( 20452100) Asthma-chronic obstructive pulmonary disease overlap syndrome ( 30657218) Autoimmune thyroid disease ( 32581359) Barrett's esophagus ( 27527254) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Bipolar disorder ( 34002096 31043756) Bipolar disorder and schizophrenia ( 22688191) BMI x environmental factors (excluding physical activity) interaction ( 33654129) Body mass index ( 30108283 31453325) Body mass index variance ( 31453325) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Bulimia nervosa ( 23568457) Chronotype ( 26835600) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cooked vegetable consumption ( 32066663) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Depression ( 33859377) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Estimated glomerular filtration rate ( 31152163) Feeling worry ( 29500382) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol levels ( 32203549) Hypertension ( 19430479) Insomnia ( 32332799) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Irritable mood ( 29500382) Joint mobility (Beighton score) ( 27182965) Liver enzyme levels (alanine transaminase) ( 33972514) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Medication use (thyroid preparations) ( 31015401) Myopia (pathological) ( 23049088) Neurociticism ( 29500382) Nose size ( 27182965) Obesity (early onset extreme) ( 20421936) Oily fish consumption ( 32066663) Plasma kynurenine to tryptophan ratio in major depressive disorder ( 29317604) Pork consumption ( 32066663) Processed meat consumption ( 32066663) Pulse pressure ( 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Raw vegetable consumption ( 32066663) Refractive error ( 32231278) Remission after SSRI treatment in MDD or neuroticism ( 29559929) Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) ( 25117820) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417) Schizophrenia ( 21679298 30285260 26198764 28991256) Serum metabolite levels ( 33031748) Smoking initiation (ever regular vs never regular) ( 30679032) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 30578418 30224653) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) TPE interval (resting) ( 32386560) Triglyceride levels ( 32203549) Type 2 diabetes ( 30297969) Waist circumference ( 30108283) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Weight ( 30108283)	A body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 20189936) Hip circumference adjusted for BMI ( 34021172) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		14 interacting genes: ARID2 CCNI COPB2 COPS5 CTNNA3 EFCAB11 FARSB FBXL3 HPCAL4 HSPA4L P4HA3 SDHB SELENBP1 WDR44	8 interacting genes: ABCA1 CARTPT GEM MSRA PIK3R5 SPRY2 TMEM132D XRN1
Entrez ID		4482	6390
HPRD ID		03152	01707
Ensembl ID		ENSG00000175806	ENSG00000117118
Uniprot IDs		Q9UJ68	A0AAQ5BHD9 P21912
PDB IDs			7KCL 7KCM 7KLU 7KLV 8GS8
Enriched GO Terms of Interacting Partners?			Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Rho Protein Signal Transduction
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