MSI1 and MIR29B1

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MSI1	MIR29B1
Description		musashi RNA binding protein 1	microRNA 29b-1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Extracellular Space Nucleus Cytoplasm Mitochondrion RISC Complex Extracellular Exosome Extracellular Vesicle
	Molecular Function	Nucleic Acid Binding RNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding Poly(U) RNA Binding Identical Protein Binding Protein Homodimerization Activity Molecular Condensate Scaffold Activity	MRNA 3'-UTR Binding LncRNA Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	Regulation Of Translation Nervous System Development Central Nervous System Development Response To Hormone Epithelial Cell Differentiation	Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Collagen Biosynthetic Process Negative Regulation Of Type III Interferon Production Negative Regulation Of Rac Protein Signal Transduction MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Epigenetic Regulation Of Gene Expression Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Secretion Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Membrane Repolarization Regulation Of Blood Vessel Remodeling Negative Regulation Of Circulating Fibrinogen Levels Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Virus Negative Regulation Of Interleukin-32 Production Negative Regulation Of Extracellular Matrix Assembly Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Mesenchymal Stem Cell Proliferation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Aorta Morphogenesis Negative Regulation Of Collagen Fibril Organization Negative Regulation Of Matrix Metallopeptidase Secretion Regulation Of Epithelium Regeneration Negative Regulation Of Intestinal Epithelial Cell Development Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Hip circumference adjusted for BMI ( 34021172) Rheumatoid arthritis ( 30891314) Spontaneous preterm birth with premature rupture of membranes ( 31194736) Waist-to-hip ratio adjusted for BMI ( 28552196)	Pancreatic cancer ( 25086665) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		27 interacting genes: APP HNRNPF HNRNPH2 MIR128-2 MIR15B MIR18A MIR19A MIR19B2 MIR20A MIR221 MIR29B1 MIR29B2 MIR29C MIR34B MIR34C MIR7-2 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7C MIRLET7D MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PNMA1	72 interacting genes: APOBEC3B C1QBP DARS1 DDX1 DDX21 DDX3X DHX36 EIF2AK2 EPRS1 FAM98A FUS G3BP2 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 MYEF2 NOL6 NONO PDCD11 PLOD1 PRMT1 PTBP1 PTBP3 PUF60 PURA RBFOX2 RBM14 RBM4 RBM47 RBMS2 RTCB SF3B1 SF3B3 SFPQ SPOUT1 STRBP SUGP2 SYNCRIP TAF15 TRA2A TRA2B TRIM25 TRIM71 UPF1 UTP20 YBX1 YBX3 ZFR ZNF346
Entrez ID		4440	407024
HPRD ID		04509
Ensembl ID		ENSG00000135097	ENSG00000283797
Uniprot IDs		O43347
PDB IDs
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Extracellular Vesicle MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway MRNA 3'-UTR Binding Negative Regulation Of Sprouting Angiogenesis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Gene Expression MRNA Destabilization RNA Destabilization Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Positive Regulation Of MRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Sprouting Angiogenesis Negative Regulation Of Translation Negative Regulation Of Signal Transduction Negative Regulation Of Extracellular Matrix Organization Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of MRNA Stability Regulation Of Metabolic Process Extracellular Space Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of RNA Stability Regulation Of Angiogenesis Negative Regulation Of Extracellular Matrix Assembly Regulation Of Vasculature Development Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Multicellular Organismal Process Regulation Of Translation Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Blood Vessel Endothelial Cell Migration	RNA Binding Nucleic Acid Binding RNA Processing RNA Splicing RNA Metabolic Process Nucleic Acid Metabolic Process MRNA Processing MRNA Binding MRNA Metabolic Process Regulation Of MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of RNA Splicing Post-transcriptional Regulation Of Gene Expression Nucleus Ribonucleoprotein Complex Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing RNA Splicing, Via Transesterification Reactions Regulation Of Translation Regulation Of MRNA Splicing, Via Spliceosome MRNA 3'-UTR Binding MiRNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Cytoplasmic Stress Granule Negative Regulation Of RNA Catabolic Process Spliceosomal Complex Negative Regulation Of MRNA Catabolic Process Negative Regulation Of Translation RNA Stabilization Regulation Of Macromolecule Metabolic Process Catalytic Step 2 Spliceosome Regulation Of Primary Metabolic Process Nucleoplasm MRNA Stabilization Regulation Of RNA Stability Positive Regulation Of Gene Expression Regulation Of MRNA Stability Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cytoplasmic Translation Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process
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