MSI1 and MIRLET7F2

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MSI1	MIRLET7F2
Description		musashi RNA binding protein 1	microRNA let-7f-2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	RISC Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding Poly(U) RNA Binding Identical Protein Binding Protein Homodimerization Activity Molecular Condensate Scaffold Activity
	Biological Process	Regulation Of Translation Nervous System Development Central Nervous System Development Response To Hormone Epithelial Cell Differentiation	MiRNA-mediated Post-transcriptional Gene Silencing
Pathways		Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Hip circumference adjusted for BMI ( 34021172) Rheumatoid arthritis ( 30891314) Spontaneous preterm birth with premature rupture of membranes ( 31194736) Waist-to-hip ratio adjusted for BMI ( 28552196)	Bipolar disorder ( 31043756)
Interacting Genes		27 interacting genes: APP HNRNPF HNRNPH2 MIR128-2 MIR15B MIR18A MIR19A MIR19B2 MIR20A MIR221 MIR29B1 MIR29B2 MIR29C MIR34B MIR34C MIR7-2 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7C MIRLET7D MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PNMA1	95 interacting genes: ADARB1 AIMP1 AIMP2 APOBEC3B ATXN2L C1QBP CPSF1 CPSF2 CPSF6 CRTAP CSTF3 DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EIF2AK2 EPRS1 ESRP1 FAM98A FAM98B FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PDCD11 PLOD1 PRMT1 PTBP1 PTCD3 PUF60 PUM1 PUM2 PURA RARS1 RBFOX2 RBM14 RBM4 RTCA RTCB SF3A1 SF3B1 SF3B2 SF3B3 SFPQ SPOUT1 STRBP SUGP2 SYNCRIP TAF15 TENT2 TRA2B TRIM71 TUT4 TUT7 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346
Entrez ID		4440	406889
HPRD ID		04509
Ensembl ID		ENSG00000135097	ENSG00000208012
Uniprot IDs		O43347
PDB IDs
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Extracellular Vesicle MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway MRNA 3'-UTR Binding Negative Regulation Of Sprouting Angiogenesis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Gene Expression MRNA Destabilization RNA Destabilization Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Positive Regulation Of MRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Sprouting Angiogenesis Negative Regulation Of Translation Negative Regulation Of Signal Transduction Negative Regulation Of Extracellular Matrix Organization Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of MRNA Stability Regulation Of Metabolic Process Extracellular Space Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of RNA Stability Regulation Of Angiogenesis Negative Regulation Of Extracellular Matrix Assembly Regulation Of Vasculature Development Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Multicellular Organismal Process Regulation Of Translation Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Blood Vessel Endothelial Cell Migration	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process MRNA Metabolic Process MRNA Processing Nucleobase-containing Compound Metabolic Process RNA Splicing MRNA Binding Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process MiRNA Binding Nucleus Regulation Of RNA Splicing Ribonucleoprotein Complex Nucleoplasm Aminoacyl-tRNA Synthetase Multienzyme Complex Regulation Of Translation Cytoplasmic Stress Granule MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Catalytic Step 2 Spliceosome Regulation Of RNA Stability Regulation Of MRNA Stability MRNA 3'-UTR Binding Negative Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Spliceosomal Complex MiRNA Processing Negative Regulation Of RNA Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of MRNA Processing RNA 3'-end Processing Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Translation Regulation Of Primary Metabolic Process Negative Regulation Of MRNA Catabolic Process Regulation Of Metabolic Process RNA Stabilization Negative Regulation Of Macromolecule Metabolic Process MRNA Stabilization Negative Regulation Of Gene Expression Negative Regulation Of Metabolic Process Positive Regulation Of Cytoplasmic Translation TRNA Metabolic Process Paraspeckles Nucleolus
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