MSI1 and MIR18A

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MSI1	MIR18A
Description		musashi RNA binding protein 1	microRNA 18a
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Extracellular Space RISC Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleic Acid Binding RNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding Poly(U) RNA Binding Identical Protein Binding Protein Homodimerization Activity Molecular Condensate Scaffold Activity	MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	Regulation Of Translation Nervous System Development Central Nervous System Development Response To Hormone Epithelial Cell Differentiation	Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Osteoblast Differentiation Positive Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Extracellular Matrix Assembly Negative Regulation Of Sprouting Angiogenesis Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching
Pathways		Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Hip circumference adjusted for BMI ( 34021172) Rheumatoid arthritis ( 30891314) Spontaneous preterm birth with premature rupture of membranes ( 31194736) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		27 interacting genes: APP HNRNPF HNRNPH2 MIR128-2 MIR15B MIR18A MIR19A MIR19B2 MIR20A MIR221 MIR29B1 MIR29B2 MIR29C MIR34B MIR34C MIR7-2 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7C MIRLET7D MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PNMA1	72 interacting genes: AIMP2 APOBEC3B C1QBP CPSF1 CRTAP DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EIF2AK2 EPRS1 FAM98A FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KNOP1 LARP7 LARS1 LIN28A LRPPRC MARS1 MATR3 MSI1 MSI2 NOL6 NONO NUDT21 NUFIP2 PDCD11 PLOD1 PTBP1 PTBP3 PUF60 QARS1 RARS1 RBFOX2 RBM14 RTCA RTCB SART3 SF3A1 SF3B1 SF3B2 SF3B3 SFPQ SYMPK SYNCRIP TAF15 TRA2A TRA2B U2SURP UPF1 UTP20 YBX1 YBX3 ZFR
Entrez ID		4440	406953
HPRD ID		04509
Ensembl ID		ENSG00000135097	ENSG00000283815
Uniprot IDs		O43347
PDB IDs
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Extracellular Vesicle MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway MRNA 3'-UTR Binding Negative Regulation Of Sprouting Angiogenesis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Gene Expression MRNA Destabilization RNA Destabilization Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Positive Regulation Of MRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Sprouting Angiogenesis Negative Regulation Of Translation Negative Regulation Of Signal Transduction Negative Regulation Of Extracellular Matrix Organization Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of MRNA Stability Regulation Of Metabolic Process Extracellular Space Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of RNA Stability Regulation Of Angiogenesis Negative Regulation Of Extracellular Matrix Assembly Regulation Of Vasculature Development Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Multicellular Organismal Process Regulation Of Translation Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Blood Vessel Endothelial Cell Migration	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process RNA Splicing MRNA Processing Nucleic Acid Metabolic Process MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process RNA Splicing, Via Transesterification Reactions Macromolecule Metabolic Process Regulation Of RNA Splicing Nucleus Aminoacyl-tRNA Synthetase Multienzyme Complex Spliceosomal Complex Catalytic Step 2 Spliceosome Ribonucleoprotein Complex Nucleoplasm Negative Regulation Of MRNA Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Cytoplasmic Stress Granule Negative Regulation Of RNA Catabolic Process Regulation Of Translation Negative Regulation Of MRNA Catabolic Process RNA Stabilization MRNA 3'-UTR Binding MRNA Stabilization Positive Regulation Of Cytoplasmic Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Regulation Of Macromolecule Metabolic Process TRNA Aminoacylation Regulation Of MRNA Stability Regulation Of Primary Metabolic Process CRD-mediated MRNA Stabilization MRNA 5'-UTR Binding RNA Transport Regulation Of RNA Stability Ligase Activity Positive Regulation Of Gene Expression Negative Regulation Of Translation Nucleolus TRNA Metabolic Process
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