MIR29B1 and LIN28B

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR29B1	LIN28B
Description		microRNA 29b-1	lin-28 RNA binding posttranscriptional regulator B
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Mitochondrion RISC Complex Extracellular Exosome Extracellular Vesicle	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	MRNA 3'-UTR Binding LncRNA Binding MRNA Base-pairing Post-transcriptional Repressor Activity	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Collagen Biosynthetic Process Negative Regulation Of Type III Interferon Production Negative Regulation Of Rac Protein Signal Transduction MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Epigenetic Regulation Of Gene Expression Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Secretion Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Membrane Repolarization Regulation Of Blood Vessel Remodeling Negative Regulation Of Circulating Fibrinogen Levels Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Virus Negative Regulation Of Interleukin-32 Production Negative Regulation Of Extracellular Matrix Assembly Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Mesenchymal Stem Cell Proliferation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Aorta Morphogenesis Negative Regulation Of Collagen Fibril Organization Negative Regulation Of Matrix Metallopeptidase Secretion Regulation Of Epithelium Regeneration Negative Regulation Of Intestinal Epithelial Cell Development Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	MiRNA Catabolic Process Post-transcriptional Regulation Of Gene Expression Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing RNA 3'-end Processing RNA Destabilization Positive Regulation Of MiRNA Catabolic Process Negative Regulation Of Pre-miRNA Processing Negative Regulation Of Primary MiRNA Processing
Pathways
Drugs
Diseases
GWAS		Pancreatic cancer ( 25086665) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Age at menarche ( 30044860) Age at voice drop ( 27182965) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Digit length ratio ( 20303062 29659830) Digit length ratio (left hand) ( 29659830) Digit length ratio (right hand) ( 29659830) Height ( 18391951 28552196 18391950 25429064 25282103 20881960 23563607) Hip circumference adjusted for BMI ( 25673412 34021172) Insomnia ( 32332799) Intraocular pressure ( 29617998 30054594) Major depressive disorder ( 27479909) Menarche (age at onset) ( 21102462 19448623 29773799 19448622 23667675 19448620 27182965 25231870) Menarche and menopause (age at onset) ( 19448621) Metabolite levels ( 23823483) Neuroblastoma ( 22941191) Pubertal anthropometrics ( 23449627) Puberty onset ( 24770850) Puberty onset (breast development) ( 24770850) Schizophrenia ( 28991256 30285260) Sporadic neuroblastoma ( 28545128) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in inactive individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 25673412 34021172) White blood cell count ( 32888494)
Interacting Genes		72 interacting genes: APOBEC3B C1QBP DARS1 DDX1 DDX21 DDX3X DHX36 EIF2AK2 EPRS1 FAM98A FUS G3BP2 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 MYEF2 NOL6 NONO PDCD11 PLOD1 PRMT1 PTBP1 PTBP3 PUF60 PURA RBFOX2 RBM14 RBM4 RBM47 RBMS2 RTCB SF3B1 SF3B3 SFPQ SPOUT1 STRBP SUGP2 SYNCRIP TAF15 TRA2A TRA2B TRIM25 TRIM71 UPF1 UTP20 YBX1 YBX3 ZFR ZNF346	46 interacting genes: AURKB KAT2B MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR143 MIR145 MIR15A MIR19B1 MIR200A MIR205 MIR206 MIR221 MIR25 MIR29A MIR29B1 MIR29B2 MIR31 MIR34A MIR34B MIR429 MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I OTUD6B
Entrez ID		407024	389421
HPRD ID			13366
Ensembl ID		ENSG00000283797	ENSG00000187772
Uniprot IDs			A0A1B0GVD3 Q6ZN17
PDB IDs			4A4I
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Splicing RNA Metabolic Process Nucleic Acid Metabolic Process MRNA Processing MRNA Binding MRNA Metabolic Process Regulation Of MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of RNA Splicing Post-transcriptional Regulation Of Gene Expression Nucleus Ribonucleoprotein Complex Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing RNA Splicing, Via Transesterification Reactions Regulation Of Translation Regulation Of MRNA Splicing, Via Spliceosome MRNA 3'-UTR Binding MiRNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Cytoplasmic Stress Granule Negative Regulation Of RNA Catabolic Process Spliceosomal Complex Negative Regulation Of MRNA Catabolic Process Negative Regulation Of Translation RNA Stabilization Regulation Of Macromolecule Metabolic Process Catalytic Step 2 Spliceosome Regulation Of Primary Metabolic Process Nucleoplasm MRNA Stabilization Regulation Of RNA Stability Positive Regulation Of Gene Expression Regulation Of MRNA Stability Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cytoplasmic Translation Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA 3'-UTR Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Extracellular Vesicle Negative Regulation Of Translation MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process Regulation Of Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Translation Negative Regulation Of Cell Migration Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of MRNA Metabolic Process Extracellular Space Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Cell Motility Positive Regulation Of Catabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Locomotion Negative Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling
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