MPI and BDKRB2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		MPI	BDKRB2
Description		mannose phosphate isomerase	bradykinin receptor B2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Endosome Plasma Membrane Membrane
	Molecular Function	Mannose-6-phosphate Isomerase Activity Protein Binding Zinc Ion Binding Isomerase Activity Metal Ion Binding	Protease Binding Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Bradykinin Receptor Activity Protein Binding Type 1 Angiotensin Receptor Binding Protein Heterodimerization Activity
	Biological Process	Carbohydrate Metabolic Process GDP-mannose Biosynthetic Process Mannose To Fructose-6-phosphate Catabolic Process GDP-D-mannose Biosynthetic Process From Fructose-6-phosphate	System Process Smooth Muscle Contraction Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Circulation Response To Salt Stress Regulation Of Vasoconstriction Vasoconstriction Vasodilation Regulation Of Vascular Permeability Arachidonate Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator
Pathways		Defective MPI causes MPI-CDG Synthesis of GDP-mannose	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs			Anatibant Icatibant Labradimil
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Mean arterial pressure ( 27618448) Red cell distribution width ( 32888494) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Cerebrospinal fluid AB1-42 levels ( 28247064) Corneal astigmatism ( 30306274) Gout ( 22179738) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales) ( 33208821) Mumps ( 28928442) Subcutaneous adipose tissue ( 26480920)
Interacting Genes		4 interacting genes: APP BDKRB2 CFTR SUMO2	33 interacting genes: AATK ACE AGTR1 AP2M1 CD81 CD82 CLCA4 EFS GNA11 GRK2 GRK3 GRK4 GRK5 GRK6 HERC2 INF2 MPI NIF3L1 NOS1 NOS3 PEX16 PRKCD PTPN11 SLC2A8 SLC35A4 SPG7 SPNS1 SYNE1 SYNGR2 TMEM11 TMEM70 TPI1 USP4
Entrez ID		4351	624
HPRD ID		01108	00213
Ensembl ID		ENSG00000178802	ENSG00000168398
Uniprot IDs		B4DW50 F5GX71 H3BPB8 H3BPP3 P34949 Q8NHZ6	P30411
PDB IDs			7F2O 7F6H 7F6I
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding Amyloid-beta Complex PTB Domain Binding Response To Purine-containing Compound Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Recycling Endosome Endosome Amylin Binding Endosome To Plasma Membrane Transport Vesicle Cell Maturation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To CAMP Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To CAMP Bradykinin Receptor Activity Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Proteolysis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Developmental Maturation Early Endosome Membrane Axon Midline Choice Point Recognition Positive Regulation Of Protein Catabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress	G Protein-coupled Receptor Kinase Activity Beta-adrenergic Receptor Kinase Activity Receptor Internalization Regulation Of G Protein-coupled Receptor Signaling Pathway Bradykinin Receptor Binding Vasodilation Protein Serine/threonine Kinase Activity Blood Vessel Diameter Maintenance Regulation Of Tube Size Nitric-oxide Synthase Activity Tetrahydrobiopterin Binding Regulation Of The Force Of Heart Contraction Regulation Of Blood Pressure Receptor-mediated Endocytosis Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Cadmium Ion Binding Protein Kinase Activity Regulation Of The Force Of Heart Contraction By Chemical Signal Desensitization Of G Protein-coupled Receptor Signaling Pathway Negative Adaptation Of Signaling Pathway L-arginine Catabolic Process Regulation Of Systemic Arterial Blood Pressure Tachykinin Receptor Signaling Pathway Arginine Binding Regulation Of Blood Circulation Kinase Activity Plasma Membrane Membrane Vascular Process In Circulatory System Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin FMN Binding Circulatory System Process G Protein-coupled Receptor Binding Regulation Of Heart Contraction G Protein-coupled Receptor Signaling Pathway Regulation Of Transport Regulation Of Biological Quality Regulation Of System Process Arginine Metabolic Process Negative Regulation Of Platelet Activation Angiotensin-activated Signaling Pathway Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Nitric Oxide Mediated Signal Transduction G Protein-coupled Acetylcholine Receptor Signaling Pathway Metalloendopeptidase Activity Nitric Oxide Biosynthetic Process Positive Regulation Of Transport Regulation Of Cell Communication Regulation Of Signaling
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