MPI

Description		mannose phosphate isomerase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Mannose-6-phosphate Isomerase Activity Protein Binding Zinc Ion Binding Isomerase Activity Metal Ion Binding
	Biological Process	Carbohydrate Metabolic Process GDP-mannose Biosynthetic Process Mannose To Fructose-6-phosphate Catabolic Process GDP-D-mannose Biosynthetic Process From Fructose-6-phosphate
Pathways		Defective MPI causes MPI-CDG Synthesis of GDP-mannose
Drugs
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Mean arterial pressure ( 27618448) Red cell distribution width ( 32888494) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Novel Interacting Genes		1 novel interacting genes: GOLGA3
Interacting Genes		4 interacting genes: APP BDKRB2 CFTR SUMO2
Entrez ID		4351
HPRD ID		01108
Ensembl ID		ENSG00000178802
Uniprot IDs		B4DW50 F5GX71 H3BPB8 H3BPP3 P34949 Q8NHZ6
PDB IDs
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding Amyloid-beta Complex PTB Domain Binding Response To Purine-containing Compound Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Recycling Endosome Endosome Amylin Binding Endosome To Plasma Membrane Transport Vesicle Cell Maturation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To CAMP Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To CAMP Bradykinin Receptor Activity Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Proteolysis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Developmental Maturation Early Endosome Membrane Axon Midline Choice Point Recognition Positive Regulation Of Protein Catabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress
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