MNT and MLX

Number of citations of the paper that reports this interaction (PMID 11230181)
26

Data Source:
BioGRID (pull down)
HPRD (in vitro, two hybrid)

		MNT	MLX
Gene Name		MAX network transcriptional repressor	MLX, MAX dimerization protein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Dimerization Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Cell Aging Negative Regulation Of Cell Proliferation Regulation Of Cell Cycle Negative Regulation Of Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Energy Reserve Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Nucleocytoplasmic Transport Positive Regulation Of Cellular Metabolic Process Small Molecule Metabolic Process Negative Regulation Of Transcription, DNA-templated
Pathways			Integration of energy metabolism ChREBP activates metabolic gene expression
Drugs
Diseases
GWAS			Crohn's disease ( 21102463)
Protein-Protein Interactions		4 interactors: HMGB1 MAX MLX SIN3A	13 interactors: AES APP GABARAPL2 ID3 MAD1L1 MLXIP MLXIPL MNT MXD1 MXD4 RBM39 SAP30BP ZBTB32
Entrez ID		4335	6945
HPRD ID		04331	04278
Ensembl ID		ENSG00000070444	ENSG00000108788
Uniprot IDs		Q99583	Q9UH92
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Regulation Of DNA Binding Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Methylglyoxal Negative Regulation Of Apoptotic Cell Clearance Negative Regulation Of Histone H3-K27 Acetylation Transcription From RNA Polymerase II Promoter Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Chromatin Silencing Negative Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Regulation Of Binding Base-excision Repair, DNA Ligation Cellular Response To Stress Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process DNA Ligation Involved In DNA Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Apoptotic Cell Clearance Regulation Of Gene Expression Negative Regulation Of Phagocytosis Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress DNA Ligation Dendritic Cell Chemotaxis Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Circadian Rhythm Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Defense Response To Virus By Host Nitrogen Compound Metabolic Process Apoptotic DNA Fragmentation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Transcription, DNA-templated Negative Regulation Of Histone Acetylation Chromatin Modification Regulation Of Gene Silencing Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Peptidyl-lysine Acetylation RNA Biosynthetic Process	Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Cell Cycle Regulation Of Cellular Process Cellular Metabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Carbohydrate Metabolic Process By Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metaphase Plate Congression Glucose Mediated Signaling Pathway Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Protein Metabolic Process Synaptic Growth At Neuromuscular Junction Regulation Of Protein Processing Carbohydrate Mediated Signaling Collateral Sprouting In Absence Of Injury Negative Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Oxidative Phosphorylation Positive Regulation Of Anoikis Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Protein Binding
Tagcloud ?		a549 bacillus bcg bovis calmette cervix coexistence constitute cop1 explanations facilitating guerin hct116 hedgehog immunoblotting immunotherapy mycobacteria mycobacterial niche originating probable shh sonic substantiating t24 tumorigenic tumorigenicity validate xenografted	accumulate acetyltransferase adapt bhlhzip circuitry defective fitness fundamental glucose helix homeostasis intracellular leucine mechanistic mondoa next occupancy organismal requirement respond sense simply steps stimulate stimulates transcriptionally trigger underlies zipper
Tagcloud (Difference) ?		a549 bacillus bcg bovis calmette cervix coexistence constitute cop1 explanations facilitating guerin hct116 hedgehog immunoblotting immunotherapy mycobacteria mycobacterial niche originating probable shh sonic substantiating t24 tumorigenic tumorigenicity validate xenografted	accumulate acetyltransferase adapt bhlhzip circuitry defective fitness fundamental glucose helix homeostasis intracellular leucine mechanistic mondoa next occupancy organismal requirement respond sense simply steps stimulate stimulates transcriptionally trigger underlies zipper
Tagcloud (Intersection) ?